Valente Denis Souto, Ely Pedro Bins, Kieling Lucas, Konzen Ana Terezinha, Steffen Lucas Pastori, Lazzaretti Gloria Sulczinski, Zanella Rafaela Koehler
Division of Surgical Clinics, Federal University of Medical Sciences of Porto Alegre, Porto Alegre, RS, Brazil.
School of Medicine, Federal University of Medical Sciences of Porto Alegre, Porto Alegre, RS, Brazil.
Transl Breast Cancer Res. 2024 Apr 29;5:14. doi: 10.21037/tbcr-23-54. eCollection 2024.
Autologous fat transfer (AFT) is gaining popularity in breast surgery, offering a natural-looking and minimally invasive approach for augmentation, reconstruction, and contouring. However, concerns about its impact on breast cancer necessitate an understanding of the interplay between transplanted adipose-derived stem cells (ADSCs) and the breast tissue microenvironment. Renowned for regeneration, ADSCs raise questions about their role in cancer promotion. This systematic review delves into the complex relationship between AFT and breast cancer, exploring how ADSCs may influence development, growth, and metastasis.
A systematic search of electronic databases, including PubMed, Embase, and BVS was conducted to identify relevant studies. The search strategy employed a combination of keywords, including "breast augmentation", "fat grafting", "breast enhancement", "mammoplasty", "cancer", "neoplasm" and related terms. Two reviewers independently screened titles and abstracts. Full-text articles were then retrieved for further evaluation based on their potential contribution to the review objectives.
Two hundred and forty records were identified. Among these, 104 duplicates were removed, resulting in 136 reports available for title and abstract screening. Subsequently, 54 papers were deemed potentially eligible for inclusion, and all reports were retrieved.
studies reveal ADSCs dual role in breast cancer, influencing proliferation, migration, and drug resistance through complex signaling pathways. Animal studies highlight distinct ADSC subpopulations impacting tumor growth via direct interactions and extracellular vesicle cargo. , ADSC-enriched fat grafting is generally safe, showing no increased cancer recurrence risk compared to other methods. Notably, cases of invasive breast carcinoma warrant special attention. ADSC-enriched fat grafts exhibit potential benefits in graft retention and survival rates. Despite promising evidence, further studies are needed to comprehensively understand the intricate relationship between ADSCs and breast cancer for optimized clinical applications and potential therapeutic innovations.
自体脂肪移植（AFT）在乳房手术中越来越受欢迎，为隆胸、乳房重建和塑形提供了一种外观自然且微创的方法。然而，对其对乳腺癌影响的担忧使得有必要了解移植的脂肪来源干细胞（ADSCs）与乳腺组织微环境之间的相互作用。ADSCs以其再生能力而闻名，这引发了关于它们在癌症促进中作用的疑问。本系统评价深入探讨了AFT与乳腺癌之间的复杂关系，探究ADSCs如何影响癌症的发生、发展和转移。
对包括PubMed、Embase和BVS在内的电子数据库进行系统检索，以识别相关研究。检索策略采用了关键词组合，包括“隆胸”“脂肪移植”“乳房增大”“乳房成形术”“癌症”“肿瘤”及相关术语。两名评审员独立筛选标题和摘要。然后根据全文文章对综述目标的潜在贡献检索全文进行进一步评估。
共识别出240条记录。其中，去除了104条重复记录，得到136篇可供标题和摘要筛选的报告。随后，54篇论文被认为可能符合纳入标准，并检索了所有报告。
研究揭示了ADSCs在乳腺癌中的双重作用，通过复杂的信号通路影响细胞增殖、迁移和耐药性。动物研究突出了不同的ADSC亚群通过直接相互作用和细胞外囊泡货物影响肿瘤生长。富含ADSC的脂肪移植总体上是安全的，与其他方法相比未显示出癌症复发风险增加。值得注意的是，浸润性乳腺癌病例值得特别关注。富含ADSC的脂肪移植在移植保留率和存活率方面显示出潜在益处。尽管有令人鼓舞的证据，但仍需要进一步研究以全面了解ADSCs与乳腺癌之间的复杂关系，以实现优化的临床应用和潜在的治疗创新。
