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1例狂犬病疫苗接种后斑秃：未报告的不良反应？

A case of alopecia areata after rabies vaccination: unreported adverse effect?

作者信息

Qiu Guiying, Chen Xinrong

机构信息

Department of Dermatology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Department of Dermatology, Zhuji People's Hospital of Zhejiang Province, Shaoxing, China.

出版信息

Clin Exp Vaccine Res. 2024 Apr;13(2):171-173. doi: 10.7774/cevr.2024.13.2.171. Epub 2024 Apr 30.

DOI:10.7774/cevr.2024.13.2.171
PMID:38752007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11091431/
Abstract

Alopecia areata (AA) is an autoimmune-related disorder characterized by non-scarring hair loss in children. We report the case of a child who had AA after the fifth dose of rabies vaccine and summarized various potential mechanisms of vaccination induced AA. This case indicates that rabies vaccine might be a predisposition of AA by causing immune dysregulation.

摘要

斑秃（AA）是一种与自身免疫相关的疾病，其特征是儿童出现非瘢痕性脱发。我们报告了一例在接种第五剂狂犬病疫苗后发生斑秃的儿童病例，并总结了疫苗诱导斑秃的各种潜在机制。该病例表明，狂犬病疫苗可能通过引起免疫失调而成为斑秃的诱因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299a/11091431/4a323532f519/cevr-13-171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299a/11091431/9d15d13bd75c/cevr-13-171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299a/11091431/4a323532f519/cevr-13-171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299a/11091431/9d15d13bd75c/cevr-13-171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299a/11091431/4a323532f519/cevr-13-171-g002.jpg

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本文引用的文献

1
Immune Response of Inactivated Rabies Vaccine Inoculated via Intraperitoneal, Intramuscular, Subcutaneous and Needle-Free Injection Technology-Based Intradermal Routes in Mice.经腹腔、肌肉、皮下和无针注射技术皮内途径接种狂犬病疫苗对小鼠的免疫应答。
Int J Mol Sci. 2023 Sep 2;24(17):13587. doi: 10.3390/ijms241713587.
2
Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways.斑秃的心理应激发病机制：自身免疫和细胞凋亡途径。
Int J Mol Sci. 2023 Jul 20;24(14):11711. doi: 10.3390/ijms241411711.
3
A Case Series and Literature Review of Telogen Effluvium and Alopecia Universalis after the Administration of a Heterologous COVID-19 Vaccine Scheme.
异源新冠疫苗接种方案后休止期脱发和普秃的病例系列及文献综述
Vaccines (Basel). 2023 Feb 15;11(2):444. doi: 10.3390/vaccines11020444.
4
A Case of Late-Onset Alopecia Areata.一例迟发性斑秃。
J Drugs Dermatol. 2022 Apr 1;21(4):420-421. doi: 10.36849/JDD.5815.
5
The how's and what's of vaccine reactogenicity.疫苗反应原性的情况与内容。
NPJ Vaccines. 2019 Sep 24;4:39. doi: 10.1038/s41541-019-0132-6. eCollection 2019.
6
Evaluation of the Relationship between Alopecia Areata and Viral Antigen Exposure.评估斑秃与病毒抗原暴露的关系。
Am J Clin Dermatol. 2018 Feb;19(1):119-126. doi: 10.1007/s40257-017-0312-y.
7
Alopecia Areata After Vaccination: Recurrence with Rechallenge.接种疫苗后发生斑秃：再次激发出现复发。
Pediatr Dermatol. 2016 May;33(3):e218-9. doi: 10.1111/pde.12849. Epub 2016 Apr 13.
8
Measles, mandates, and making vaccination the default option.麻疹、强制令以及将疫苗接种设为默认选项。
JAMA Pediatr. 2015 Apr;169(4):303-4. doi: 10.1001/jamapediatrics.2015.0291.
9
Alopecia areata update: part II. Treatment.斑秃更新：第二部分。治疗。
J Am Acad Dermatol. 2010 Feb;62(2):191-202, quiz 203-4. doi: 10.1016/j.jaad.2009.10.031.