Nisargandha Milind A, Parwe Shweta D, Lade Nitin R, Padathpeedika Khalid Jabir, Kuchewar Vaishali V
Physiology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Panchakarma, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (DMIHER), Wardha, IND.
Cureus. 2024 Apr 15;16(4):e58294. doi: 10.7759/cureus.58294. eCollection 2024 Apr.
Introduction Hansen's disease is a condition in which patients develop peripheral neuropathy. In 1873, G. H. A. Hansen discovered Mycobacterium leprae, the causative agent of leprosy, a chronic infectious disease. These bacteria influence the peripheral nerves, which is likely to cause neuropathy. Sensory nerve conduction studies were performed in leprosy patients on the upper limb nerves of 30 patients in the rural area of the Wardha district in the Indian population. Methods In this study, we recruited 30 leprosy patients from the Department of Dermatology and A.V.B.R. Hospital, Sawangi Wardha. The patient's nerve conduction velocity (NCV) tests were carried out in the Department of Physiology at J. N. Medical College, Wardha. NCVs were obtained during these three years, beginning in 2009, while performing sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV). The latency, amplitude, and NCV parameters were recorded, and the data collection period ended in 2011. In this study, we measured both MNCV and SNCV. Results In our study, impairment of conductional velocity was observed. In leprosy patients, the MNCV values of latency, amplitude, and conductional velocity were 6.61, 3.89, and 46.92 m/s, respectively, whereas the SNCV values were 3.005, 25.17, and 38 m/s, respectively. Based on the results, it appears that the maximal sensory nerve involvement was recorded at 38 m/s conductional velocity. In NCVs, increased latency and decreased conductional velocity were found across the study. Conclusion It was concluded that nerve conduction studies are one of the non-invasive techniques for early diagnosis and management of leprosy. This study should be repeated with a larger sample size and should be multicentric.
引言
麻风病是一种会使患者出现周围神经病变的疾病。1873年，G. H. A. 汉森发现了麻风分枝杆菌，即麻风病（一种慢性传染病）的病原体。这些细菌会影响周围神经，很可能导致神经病变。在印度人口中，对沃尔哈地区农村的30名麻风病患者的上肢神经进行了感觉神经传导研究。
方法
在本研究中，我们从萨万吉沃尔哈的皮肤病学与A.V.B.R.医院招募了30名麻风病患者。患者的神经传导速度（NCV）测试在沃尔哈J. N. 医学院的生理学系进行。在2009年开始的这三年里，在进行感觉神经传导速度（SNCV）和运动神经传导速度（MNCV）测试时获取了NCV值。记录了潜伏期、波幅和NCV参数，数据收集期于2011年结束。在本研究中，我们同时测量了MNCV和SNCV。
结果
在我们的研究中，观察到了传导速度受损的情况。在麻风病患者中，潜伏期、波幅和传导速度的MNCV值分别为6.61、3.89和46.92米/秒，而SNCV值分别为3.005、25.17和38米/秒。根据结果，似乎最大感觉神经受累出现在传导速度为38米/秒时。在整个研究中，发现NCV的潜伏期增加且传导速度降低。
结论
得出的结论是，神经传导研究是麻风病早期诊断和管理的非侵入性技术之一。本研究应以更大的样本量并在多中心重复进行。
