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一名患有先天性关节挛缩症的成年人膜性肾病的罕见表现:病例报告

An Unusual Presentation of Membranous Nephropathy in an Adult With Arthrogryposis: A Case Report.

作者信息

Agrawal Upasana, Sondhi Manush, Gandhi Nitesh, Sharma Shivani

机构信息

Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, USA.

出版信息

Cureus. 2024 Apr 15;16(4):e58339. doi: 10.7759/cureus.58339. eCollection 2024 Apr.

DOI:10.7759/cureus.58339
PMID:38752080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11094667/
Abstract

Membranous nephropathy (MN) is an autoimmune condition that is a common cause of nephrotic syndrome in nondiabetic adults. In this study, we highlight a case of a 22-year-old male with a past medical history of arthrogryposis multiplex congenita (AMC) who initially presented with right flank pain and hematuria. Subsequent workup revealed significant proteinuria with biopsy-proven primary MN. Early detection of the disease is critical to establish treatment promptly and prevent complications such as those resulting from a hypercoagulable state.

摘要

膜性肾病(MN)是一种自身免疫性疾病,是非糖尿病成年人肾病综合征的常见病因。在本研究中,我们重点介绍了一例22岁男性病例,该患者既往有先天性多发性关节挛缩症(AMC)病史,最初表现为右侧胁腹疼痛和血尿。后续检查发现大量蛋白尿,活检证实为原发性MN。疾病的早期检测对于及时确立治疗并预防诸如高凝状态导致的并发症至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/11094667/1cdbef05f06b/cureus-0016-00000058339-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/11094667/189d5fa685ae/cureus-0016-00000058339-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/11094667/1cdbef05f06b/cureus-0016-00000058339-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/11094667/189d5fa685ae/cureus-0016-00000058339-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/11094667/1cdbef05f06b/cureus-0016-00000058339-i02.jpg

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本文引用的文献

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A Patient with Nephrotic Syndrome and Acute Flank Pain.
Kidney360. 2020 Jan 30;1(1):74-75. doi: 10.34067/KID.0000482019.
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Membranous nephropathy.膜性肾病。
Nat Rev Dis Primers. 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z.
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AJKD Atlas of Renal Pathology: Membranous Nephropathy.《美国肾脏病学会杂志》肾脏病理学图谱:膜性肾病
Am J Kidney Dis. 2015 Sep;66(3):e15-7. doi: 10.1053/j.ajkd.2015.07.006.
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Glomerular involvement in the arthrogryposis, renal dysfunction and cholestasis syndrome.关节挛缩、肾功能不全和胆汁淤积综合征中的肾小球受累情况。
Clin Kidney J. 2013 Apr;6(2):183-8. doi: 10.1093/ckj/sfs182. Epub 2013 Jan 29.
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IgG subclass staining in renal biopsies with membranous glomerulonephritis indicates subclass switch during disease progression.在膜性肾小球肾炎的肾活检中,IgG 亚类染色表明疾病进展过程中出现了亚类转换。
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Membranous glomerulonephritis is a manifestation of IgG4-related disease.膜性肾小球肾炎是 IgG4 相关疾病的一种表现。
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IgG subclass distribution of antibody responses to protein and polysaccharide mycobacterial antigens in leprosy and tuberculosis patients.麻风病和结核病患者针对蛋白质和多糖分枝杆菌抗原的抗体反应的IgG亚类分布
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