苏比利托洛酰胺 A-D 和苏比里托吡啶 A-B：从南海海绵 Pseudospongosorites suberitoides 中分离得到的新γ-内酰胺和吡啶生物碱。
Suberitolactams A-D and Suberitopyridines A-B: New γ-lactam and Pyridine Alkaloids Isolated from the South China Sea Sponge Pseudospongosorites suberitoides.
机构信息
Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266071, People's Republic of China.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.
出版信息
Chem Biodivers. 2024 Aug;21(8):e202400939. doi: 10.1002/cbdv.202400939. Epub 2024 Jun 26.
Four new γ-lactam alkaloids, suberitolactams A-D (1-4), two new pyridine alkaloids, suberitopyridines A-B (7-8), and two known compounds (5-6) were isolated from the South China Sea sponge Pseudospongosorites suberitoides. The structures were elucidated by detailed 1D and 2D NMR experiments along with HRESIMS analysis and single crystal X-ray diffraction. Compounds 1 and 8 showed moderate to weak antiviral activity against H1 N1 virus with IC values of 27.6 and 13.3 μM, respectively.
从南海海绵 Pseudospongosorites suberitoides 中分离得到了四个新的γ-内酰胺生物碱，分别为亚丁醇内酰胺 A-D（1-4），两个新的吡啶生物碱，亚丁醇吡啶 A-B（7-8），以及两个已知化合物（5-6）。通过详细的 1D 和 2D NMR 实验以及 HRESIMS 分析和单晶 X 射线衍射，确定了它们的结构。化合物 1 和 8 对 H1N1 病毒表现出中等至较弱的抗病毒活性，IC 值分别为 27.6 和 13.3μM。
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