复方新诺明（甲氧苄啶-磺胺甲恶唑）与螺旋霉素对感染刚地弓形虫（贝弗利株）的妊娠小鼠的比较效果。
Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole) and spiramycin in pregnant mice infected with Toxoplasma gondii (Beverley strain).
作者信息
Nguyen B T, Stadtsbaeder S
出版信息
Br J Pharmacol. 1985 Jul;85(3):713-6. doi: 10.1111/j.1476-5381.1985.tb10568.x.
The effects of cotrimoxazole (CTX) and spiramycin (Spir) in mice infected in midpregnancy with the Beverley (Bev) strain of Toxoplasma gondii were compared. Therapeutic effectiveness was determined according to the following parameters: rate of successful delivery, litter size, offspring weight and survival. When compared with the uninfected untreated control group, CTX showed a more beneficial therapeutic effect than Spir, with a statistically significant increase in the rate of both successful delivery and offspring survival. Results based on antitoxoplasma antibody determinations in the offspring indicated a better in utero control of congenital infection by CTX than by Spir.
比较了复方新诺明（CTX）和螺旋霉素（Spir）对妊娠中期感染刚地弓形虫贝弗利（Bev）株小鼠的影响。根据以下参数确定治疗效果：成功分娩率、窝仔数、后代体重和存活率。与未感染未治疗的对照组相比，CTX显示出比Spir更有益的治疗效果，成功分娩率和后代存活率均有统计学意义的显著提高。基于后代抗弓形虫抗体测定的结果表明，CTX对先天性感染的宫内控制比Spir更好。
Zotero 插件