Schwartzman R J, Alexander G M
Brain Res. 1985 Jul 1;337(2):263-8. doi: 10.1016/0006-8993(85)90062-9.
Nine monkeys (Macaca fascicularis) were used in this study. Four monkeys were rendered parkinsonian by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 0.5 mg/kg intravenously. Three animals were injected once daily for 4 days, and one animal once weekly for 4 weeks. Five animals were used as controls. All MPTP-treated animals demonstrated the same clinical features which included akinesia, bradykinesia, a flexed posture of the trunk and all extremities, decreased initiation of the threat response, decreased vocalization and difficulty in swallowing. An increase in rigidity and reflexes was noted in all extremities. Tremor was present in all animals. Determination of the local spinal metabolic rate of glucose (LSMRg) utilization revealed an increase (P less than 0.05) in LSMRg in Rexed layer I in all cord segments and in Rexed layer II in both cervical and lumbar segments. Rexed layer X demonstrated a significant (P less than 0.05) increase in LSMRg at the cervical cord. The LSMRg in the animal that received weekly injections was similar to the daily injected animals.
本研究使用了9只食蟹猴（猕猴）。4只猴子通过静脉注射0.5mg/kg的1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）制成帕金森病模型。3只动物连续4天每天注射一次，1只动物连续4周每周注射一次。5只动物作为对照。所有接受MPTP治疗的动物都表现出相同的临床特征，包括运动不能、运动迟缓、躯干和四肢屈曲姿势、威胁反应启动减少、发声减少和吞咽困难。所有肢体均出现僵硬和反射增强。所有动物都有震颤。局部脊髓葡萄糖代谢率（LSMRg）测定显示，所有脊髓节段的Rexed I层以及颈段和腰段的Rexed II层的LSMRg均增加（P<0.05）。Rexed X层在颈髓处的LSMRg显著增加（P<0.05）。每周注射的动物的LSMRg与每日注射的动物相似。
