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蒙特利尔健康海地人的免疫学研究结果。

Immunologic findings in healthy Haitians in Montreal.

作者信息

Adrien A, Desrosiers M, Frappier-Davignon L, Spitzer W O, Dupuy J M

出版信息

CMAJ. 1985 Sep 1;133(5):401-6.

Abstract

To investigate the occurrence of acquired immune deficiency syndrome in Haitians, a health status questionnaire was administered and selected studies of immune status done in a randomly chosen sample of 189 healthy adult Haitians living in Montreal. The study group was comparable to a large sample of Haitians in Montreal interviewed in the 1981 census with respect to age, sex, number of persons per household and year of immigration, but the proportion of currently married people in the study was larger (60.8% v. 42.6%). The results in the study group were compared with those in a sample of 189 non-Haitians matched for age, sex and neighbourhood of residence. Persons with known causes of impaired immune function were excluded. The participation rate was 87.5%. The study and control groups both reported few symptoms and chronic health problems and had comparable demographic data, including rate of employment and income. The mean total numbers of lymphocytes, OKT3 and OKT4 (helper) and OKT8 (suppressor) cells were significantly higher in the Haitians than in the controls, though still within normal limits. There was a borderline elevation of the lymphocyte response to phytohemagglutinin in the Haitians. The ratios of helper to suppressor T cells in the two groups were, however, not significantly different. The Haitians, in comparison with non-Haitians living in the same community, had no demonstrable abnormalities of cellular immune function.

摘要

为调查海地人后天免疫缺陷综合征的发病情况,我们对189名居住在蒙特利尔的健康成年海地人进行了随机抽样,并对其进行了健康状况问卷调查及免疫状态研究。研究组在年龄、性别、家庭人口数和移民年份方面,与1981年人口普查中接受访谈的蒙特利尔大量海地人样本具有可比性,但研究组中目前已婚者的比例更高(60.8%对42.6%)。将研究组的结果与189名年龄、性别和居住社区相匹配的非海地人样本的结果进行比较。排除已知免疫功能受损原因的人。参与率为87.5%。研究组和对照组报告的症状和慢性健康问题都很少,且在人口统计学数据方面具有可比性,包括就业率和收入。海地人的淋巴细胞、OKT3、OKT4(辅助性)和OKT8(抑制性)细胞的平均总数显著高于对照组,尽管仍在正常范围内。海地人对植物血凝素的淋巴细胞反应有临界升高。然而,两组中辅助性T细胞与抑制性T细胞的比例没有显著差异。与居住在同一社区的非海地人相比,海地人的细胞免疫功能没有明显异常。

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