Stahl R E, Friedman-Kien A, Dubin R, Marmor M, Zolla-Pazner S
Am J Med. 1982 Aug;73(2):171-8. doi: 10.1016/0002-9343(82)90174-7.
Studies were performed to define the immunologic status of various groups of homosexual men including homosexual men with Kaposi's sarcoma, healthy homosexual men who were of similar ages to the homosexual patients with Kaposi's sarcoma and homosexual men with hyperplastic lymphadenopathy. Heterosexual men with Kaposi's sarcoma were also studied. Immunologic parameters which were examined included serum immunoglobulin levels, enumeration of B cells, T cells, and T-cell subsets, and quantitation of lymphocyte responsive to phytohemagglutinin (PHA) and pokeweed mitogen (PWM). Significant immunologic abnormalities were observed in all three groups of homosexuals studied. These were most severe in the homosexuals with Kaposi's sarcoma, somewhat less severe in homosexual men with lymphadenopathy, and least marked but still significant in healthy homosexual men. Heterosexual men with Kaposi's sarcoma displayed essentially normal immunologic profiles. The possible etiologic factors underlying the immunologic abnormalities in the male homosexual population studied and the role of an altered immune system in the development of and the fulminant course of Kaposi's sarcoma in these patients are discussed.
开展各项研究以明确不同组别的同性恋男性的免疫状态，其中包括患有卡波西肉瘤的同性恋男性、年龄与患有卡波西肉瘤的同性恋患者相近的健康同性恋男性以及患有增生性淋巴结病的同性恋男性。还对患有卡波西肉瘤的异性恋男性进行了研究。所检测的免疫参数包括血清免疫球蛋白水平、B细胞、T细胞及T细胞亚群的计数，以及对植物血凝素（PHA）和商陆有丝分裂原（PWM）产生反应的淋巴细胞的定量分析。在所研究的三组同性恋者中均观察到显著的免疫异常。这些异常在患有卡波西肉瘤的同性恋者中最为严重，在患有淋巴结病的同性恋男性中稍轻，而在健康同性恋男性中最不明显但仍具有显著性。患有卡波西肉瘤的异性恋男性的免疫状况基本正常。文中讨论了所研究的男性同性恋人群免疫异常的可能病因，以及免疫系统改变在这些患者卡波西肉瘤发生及暴发性病程中的作用。
