Noor Manahil, Muhammad Gulzar, Hanif Hina, Hussain Muhammad Ajaz, Iqbal Muhammad Mudassir, Mehmood Uqba, Taslimi Parham, Shafiq Zahid
Department of Chemistry, Government College University, Lahore 54000, Pakistan.
Department of Chemistry, Government College University, Lahore 54000, Pakistan.
Int J Biol Macromol. 2024 Jun;270(Pt 2):132390. doi: 10.1016/j.ijbiomac.2024.132390. Epub 2024 May 14.
Mimosa pudica (MP) is an ornamental plant due to seismonastic movements that close leaves and fall petioles in response to touch, wind, light, heat, cold, and vibration. The seeds of MP secrete smart, biocompatible, and non-toxic mucilage that has captivated researchers due to its widespread use in various fields such as pharmaceuticals and biotechnology. The mucilage is responsive to pH, salt solutions, and solvents and acts as a binder in tablet formulations for targeted drug delivery. The mucilage is chemically modifiable via acetylation, succinylation, and graft polymerization. Chemically modified MP mucilage appeared supersorbent for heavy metal ion uptake. Nanoparticles synthesized using mucilage as a reducing and capping agent displayed significant antimicrobial and wound-healing potential. Crosslinking of mucilage using citric acid as a crosslinking agent offers a sustained release of drugs. The present review is aimed to discuss extraction optimization, structure, modification, and the stimuli-responsive nature of mucilage. The review article will cover the potential of mucilage as emulsifying, suspending, bio-adhesive, gelling, and thickening agent. The role of mucilage as a capping and reducing agent for nanoparticles will also be discussed.
含羞草（MP）是一种观赏植物，因其具有感震运动，即能对触摸、风、光、热、冷和振动做出反应，使叶子闭合、叶柄下垂。含羞草的种子会分泌出智能、生物相容性好且无毒的黏液，由于其在制药和生物技术等各个领域的广泛应用，这种黏液吸引了研究人员的关注。该黏液对pH值、盐溶液和溶剂有反应，在靶向药物递送的片剂配方中可作为粘合剂。这种黏液可通过乙酰化、琥珀酰化和接枝聚合进行化学改性。化学改性的含羞草黏液对重金属离子的吸收表现出超强吸附性。以黏液作为还原剂和封端剂合成的纳米颗粒具有显著的抗菌和伤口愈合潜力。使用柠檬酸作为交联剂对黏液进行交联可实现药物的缓释。本综述旨在讨论黏液的提取优化、结构、改性以及刺激响应特性。这篇综述文章将涵盖黏液作为乳化剂、悬浮剂、生物黏附剂、胶凝剂和增稠剂的潜力。还将讨论黏液作为纳米颗粒的封端剂和还原剂的作用。
