Edmondson R A, Reading C
Drugs. 1985;29 Suppl 5:64-6. doi: 10.2165/00003495-198500295-00013.
The stability of temocillin to 12 different beta-lactamase preparations was studied using high pressure liquid chromatography and was compared with that of aztreonam, cefotetan and cefotaxime. Temocillin was the most stable beta-lactam examined, being as stable as cefotetan to most of the beta-lactamases tested. However, cefotetan was hydrolysed at measurable rates by the beta-lactamase of Enterobacter cloacae P99, in contrast to temocillin which was completely stable to this enzyme. Aztreonam was hydrolysed at a slow rate by many of the preparations, being especially labile to the enzyme from Klebsiella oxytoca K1. Cefotaxime was hydrolysed at varying rates by all the preparations.
采用高压液相色谱法研究了替莫西林对12种不同β-内酰胺酶制剂的稳定性，并与氨曲南、头孢替坦和头孢噻肟进行了比较。替莫西林是所检测的β-内酰胺类药物中最稳定的，对大多数测试的β-内酰胺酶的稳定性与头孢替坦相当。然而，头孢替坦可被阴沟肠杆菌P99的β-内酰胺酶以可测量的速率水解，而替莫西林对该酶完全稳定。许多制剂对氨曲南的水解速率较慢，尤其是对产酸克雷伯菌K1的酶特别敏感。所有制剂对头孢噻肟的水解速率各不相同。
