头孢替坦的β-内酰胺酶稳定性及体外活性；与其他8种β-内酰胺类抗生素及庆大霉素的比较。
The beta-lactamase stability and in vitro activity of cefotetan; a comparison with 8 other beta-lactam antibiotics and gentamicin.
作者信息
Friis H, Prag J, Togsverd E, Benzon M W
出版信息
Acta Pathol Microbiol Immunol Scand B. 1986 Aug;94(4):251-6. doi: 10.1111/j.1699-0463.1986.tb03049.x.
The antibacterial activity of cefotetan, 8 other beta-lactam antibiotics and gentamicin, was tested in vitro on 288 recently isolated bacteria. The activity of cefotetan was generally higher than the 2.generation cephalosporin cefuroxime and lower than the 3.generation cephalosporins tested. In addition, cefotetan was shown to have some antibacterial activity against anaerobic bacteria. Cefotetan is a cephamycin and was found resistant to all 14 plasmid-mediated and 2 chromosomally-mediated beta-lactamases. With its beta-lactamase resistance and antibacterial activity, cefotetan seems to be a "second-generation-like" cephalosporin, almost with 3.generation cephalosporin antibacterial activity against Enterobacteriaceae.
在体外对288株近期分离出的细菌测试了头孢替坦、其他8种β-内酰胺类抗生素和庆大霉素的抗菌活性。头孢替坦的活性总体上高于第二代头孢菌素头孢呋辛，低于所测试的第三代头孢菌素。此外，头孢替坦显示出对厌氧菌有一定抗菌活性。头孢替坦是一种头霉素，对所有14种质粒介导的和2种染色体介导的β-内酰胺酶均耐药。凭借其对β-内酰胺酶的耐药性和抗菌活性，头孢替坦似乎是一种“类第二代”头孢菌素，几乎具有第三代头孢菌素对肠杆菌科细菌的抗菌活性。
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