Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California.
Department for Radiology and Nuclear Medicine, Mannheim University Medical Centre, Mannheim, Germany.
J Vasc Interv Radiol. 2024 Aug;35(8):1227-1233. doi: 10.1016/j.jvir.2024.05.005. Epub 2024 May 14.
To characterize the relationship between ablation zone volume (AZV) and microwave ablation (MWA) energy in an in vivo porcine liver model following arterial embolization.
With Institutional Animal Care and Use Committee (IACUC) approval, 11 female swine underwent either right (n = 5) or left (n = 6) hepatic artery embolization under fluoroscopic guidance. Subsequently, ultrasound (US)-guided MWA was performed in each liver segment (left lateral, left medial, right medial, and right lateral) at either 30 W (n = 4 lobes), 60 W (n = 4), 65 W (n = 20), 90 W (n = 8), 120 W (n = 4), or 140 W (n = 4) continuously for 5 minutes. Postprocedural volumetric segmentation was performed on standardized multiphase T1 magnetic resonance (MR) imaging sequences.
Mean AZVs in embolized lobes (15.8 mL ± SD 10.6) were significantly larger than those in nonembolized lobes (11.2 mL ± SD 6.5, P < .01). MWA energy demonstrated significant positive linear correlation with both embolized (R = 0.66, P < .01) and nonembolized (R = 0.64, P < .01) lobes. The slope of the linear models corresponded to a 0.95 mL/kJ (SD ± 0.16) and 0.54 mL/kJ (SD ± 0.09) increase in ablation volume per applied kilojoule of energy (E) in embolized and nonembolized lobes, respectively. In the multivariate model, embolization status significantly modified the relationship between E and AZV as described by the following interaction term: 0.42∗E∗(embolization status) (P = .031).
Linear models demonstrated a near 1.8-fold increase in ratio of AZV per unit E, R(AZV:E), when applied to embolized lobes relative to nonembolized lobes. Absolute AZV differences between embolized and nonembolized lobes were greater at higher-power MWA.
在经动脉栓塞的活体猪肝脏模型中，描述消融区域体积（AZV）与微波消融（MWA）能量之间的关系。
经机构动物护理和使用委员会（IACUC）批准，11 头雌性猪在透视引导下接受右（n=5）或左（n=6）肝动脉栓塞。随后，在每个肝段（左外叶、左内叶、右内叶和右外叶）进行超声（US）引导下的 MWA，功率分别为 30 W（n=4 个叶）、60 W（n=4）、65 W（n=20）、90 W（n=8）、120 W（n=4）或 140 W（n=4），连续 5 分钟。在多期 T1 磁共振（MR）成像序列上对术后容积分段进行处理。
栓塞叶的平均 AZV（15.8 mL ± 10.6 SD）明显大于非栓塞叶（11.2 mL ± 6.5 SD，P <.01）。MWA 能量与栓塞（R=0.66，P <.01）和非栓塞（R=0.64，P <.01）叶均呈显著正线性相关。线性模型的斜率对应于栓塞和非栓塞叶中每焦耳应用能量（E）的消融体积分别增加 0.95 mL/kJ（SD ± 0.16）和 0.54 mL/kJ（SD ± 0.09）。在多变量模型中，栓塞状态通过以下交互项显著修正了 E 与 AZV 之间的关系：0.42∗E∗（栓塞状态）（P=.031）。
线性模型显示，相对于非栓塞叶，栓塞叶的 AZV 与单位 E 的比值（R（AZV：E））增加近 1.8 倍。栓塞和非栓塞叶之间的绝对 AZV 差异在更高功率的 MWA 时更大。
