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电子心脏贴片感知和修复梗死心肌。

E-cardiac patch to sense and repair infarcted myocardium.

机构信息

Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering; Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.

出版信息

Nat Commun. 2024 May 16;15(1):4133. doi: 10.1038/s41467-024-48468-x.

DOI:10.1038/s41467-024-48468-x
PMID:38755124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11099052/
Abstract

Conductive cardiac patches can rebuild the electroactive microenvironment for the infarcted myocardium but their repair effects benefit by carried seed cells or drugs. The key to success is the effective integration of electrical stimulation with the microenvironment created by conductive cardiac patches. Besides, due to the concerns in a high re-admission ratio of heart patients, a remote medicine device will underpin the successful repair. Herein, we report a miniature self-powered biomimetic trinity triboelectric nanogenerator with a unique double-spacer structure that unifies energy harvesting, therapeutics, and diagnosis in one cardiac patch. Trinity triboelectric nanogenerator conductive cardiac patches improve the electroactivity of the infarcted heart and can also wirelessly monitor electrocardiosignal to a mobile device for diagnosis. RNA sequencing analysis from rat hearts reveals that this trinity cardiac patches mainly regulates cardiac muscle contraction-, energy metabolism-, and vascular regulation-related mRNA expressions in vivo. The research is spawning a device that truly integrates an electrical stimulation of a functional heart patch and self-powered e-care remote diagnostic sensor.

摘要

导电心脏贴片可以重建梗死心肌的电活性微环境，但它们的修复效果受益于携带种子细胞或药物。成功的关键是将电刺激与导电心脏贴片所创造的微环境有效结合。此外，由于心脏病患者高再入院率的担忧，远程医疗设备将为成功修复提供支持。在这里，我们报告了一种具有独特双间隔结构的微型自供电仿生三体摩擦纳米发电机，它将能量收集、治疗和诊断统一在一个心脏贴片上。三体摩擦纳米发电机导电心脏贴片改善了梗死心脏的电活性，还可以无线监测心电图信号到移动设备进行诊断。来自大鼠心脏的 RNA 测序分析表明，这种三体心脏贴片主要调节体内心肌收缩、能量代谢和血管调节相关的 mRNA 表达。这项研究催生了一种真正将功能性心脏贴片的电刺激和自供电电子保健远程诊断传感器集成在一起的设备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/491ccc5619e9/41467_2024_48468_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/61f3c4347583/41467_2024_48468_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/837343cc0b46/41467_2024_48468_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/488a4f081680/41467_2024_48468_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/188afaff9426/41467_2024_48468_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/2e1f4fb04a44/41467_2024_48468_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/5d7661dfd682/41467_2024_48468_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/f8bb37946f00/41467_2024_48468_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/491ccc5619e9/41467_2024_48468_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/61f3c4347583/41467_2024_48468_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/837343cc0b46/41467_2024_48468_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/488a4f081680/41467_2024_48468_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/188afaff9426/41467_2024_48468_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/2e1f4fb04a44/41467_2024_48468_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/5d7661dfd682/41467_2024_48468_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/f8bb37946f00/41467_2024_48468_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/11099052/491ccc5619e9/41467_2024_48468_Fig8_HTML.jpg

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