Department of Oncology, Beijing Shijitan Hospital of Capital Medical University, 10 Tieyi Road, Beijing, 100038, China.
Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome, Italy.
Biol Direct. 2024 May 16;19(1):39. doi: 10.1186/s13062-024-00479-w.
The presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidated. The aim of this study was to investigate the functions of mesenchymal stem cells isolated from tumor tissues of patients with non-small cell lung cancer.
Human lung cancer-derived mesenchymal stem cells displayed the typical morphology and immunophenotype of mesenchymal stem cells; they were nontumorigenic and capable of undergoing multipotent differentiation. These isolated cells remarkably enhanced tumor growth when incorporated into systems alongside tumor cells in vivo. Importantly, in the presence of mesenchymal stem cells, the ability of peripheral blood mononuclear cell-derived natural killer and activated T cells to mediate tumor cell destruction was significantly compromised.
Collectively, these data support the notion that human lung cancer-derived mesenchymal stem cells protect tumor cells from immune-mediated destruction by inhibiting the antitumor activities of natural killer and T cells.
间充质干细胞存在于一些实体肿瘤中，它们是肿瘤微环境的重要组成部分；然而，它们在癌症中的作用尚未完全阐明。本研究旨在探讨从非小细胞肺癌患者肿瘤组织中分离的间充质干细胞的功能。
人肺癌衍生的间充质干细胞表现出间充质干细胞的典型形态和免疫表型；它们无致瘤性且能够进行多能分化。这些分离的细胞在体内与肿瘤细胞一起纳入系统时显著增强了肿瘤的生长。重要的是，在间充质干细胞存在的情况下，外周血单个核细胞衍生的自然杀伤细胞和活化 T 细胞介导肿瘤细胞破坏的能力显著受损。
总之，这些数据支持这样一种观点，即人肺癌衍生的间充质干细胞通过抑制自然杀伤细胞和 T 细胞的抗肿瘤活性来保护肿瘤细胞免受免疫介导的破坏。
