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衰老肺部的微环境、机制与疾病

The aging lung: microenvironment, mechanisms, and diseases.

机构信息

School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences (Sichuan Second Hospital of T.C.M), Chengdu, China.

出版信息

Front Immunol. 2024 May 2;15:1383503. doi: 10.3389/fimmu.2024.1383503. eCollection 2024.

DOI:10.3389/fimmu.2024.1383503
PMID:38756780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11096524/
Abstract

With the development of global social economy and the deepening of the aging population, diseases related to aging have received increasing attention. The pathogenesis of many respiratory diseases remains unclear, and lung aging is an independent risk factor for respiratory diseases. The aging mechanism of the lung may be involved in the occurrence and development of respiratory diseases. Aging-induced immune, oxidative stress, inflammation, and telomere changes can directly induce and promote the occurrence and development of lung aging. Meanwhile, the occurrence of lung aging also further aggravates the immune stress and inflammatory response of respiratory diseases; the two mutually affect each other and promote the development of respiratory diseases. Explaining the mechanism and treatment direction of these respiratory diseases from the perspective of lung aging will be a new idea and research field. This review summarizes the changes in pulmonary microenvironment, metabolic mechanisms, and the progression of respiratory diseases associated with aging.

摘要

随着全球社会经济的发展和人口老龄化的加深，与衰老相关的疾病受到越来越多的关注。许多呼吸系统疾病的发病机制尚不清楚，肺衰老也是呼吸系统疾病的独立危险因素。肺的衰老机制可能参与了呼吸系统疾病的发生和发展。衰老引起的免疫、氧化应激、炎症和端粒改变可直接诱导和促进肺衰老的发生和发展。同时，肺衰老的发生也进一步加重了呼吸系统疾病的免疫应激和炎症反应；两者相互影响，促进了呼吸系统疾病的发展。从肺衰老的角度来阐释这些呼吸系统疾病的发病机制和治疗方向，将是一个新的思路和研究领域。本文综述了与衰老相关的呼吸系统疾病中肺微环境、代谢机制的变化及其进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/57c0c1e9878b/fimmu-15-1383503-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/bd7d7d9c32c9/fimmu-15-1383503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/6215bcf39b36/fimmu-15-1383503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/46a847dfdf9b/fimmu-15-1383503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/73a9265616f9/fimmu-15-1383503-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/d88086c3cb9d/fimmu-15-1383503-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/92cb77063744/fimmu-15-1383503-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/57c0c1e9878b/fimmu-15-1383503-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/bd7d7d9c32c9/fimmu-15-1383503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/6215bcf39b36/fimmu-15-1383503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/46a847dfdf9b/fimmu-15-1383503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/73a9265616f9/fimmu-15-1383503-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/d88086c3cb9d/fimmu-15-1383503-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/92cb77063744/fimmu-15-1383503-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90d/11096524/57c0c1e9878b/fimmu-15-1383503-g007.jpg

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