Adachi M, Ishizaka K
Proc Natl Acad Sci U S A. 1986 Sep;83(18):7003-7. doi: 10.1073/pnas.83.18.7003.
Incubation of normal mouse splenic lymphocytes with dimeric mouse IgD results in the formation of T-cell factors that selectively inhibit rosette formation of Fc delta receptor-positive lymphocytes with IgD-coated erythrocytes. The rosette-inhibiting factors bound to IgD-Sepharose and were recovered by elution at acid pH. The results indicate that the rosette-inhibiting factors are IgD-binding factors. Neither IgE-binding factors nor IgG-binding factors inhibited IgD rosettes. The IgD-binding factors induced by IgD consist of two species of molecular weight 78,000 and 37,000, respectively. The source of IgD-binding factors is Lyt-1+ T cells bearing Fc delta receptors. It appears that the binding of IgD to the receptors on the T cells induces the formation of IgD-binding factors.
用二聚体小鼠IgD孵育正常小鼠脾淋巴细胞，会导致形成T细胞因子，这些因子可选择性抑制Fcδ受体阳性淋巴细胞与IgD包被红细胞的玫瑰花结形成。玫瑰花结抑制因子与IgD-琼脂糖结合，并通过在酸性pH下洗脱回收。结果表明，玫瑰花结抑制因子是IgD结合因子。IgE结合因子和IgG结合因子均不抑制IgD玫瑰花结。由IgD诱导的IgD结合因子分别由分子量为78,000和37,000的两种分子组成。IgD结合因子的来源是带有Fcδ受体的Lyt-1 + T细胞。似乎IgD与T细胞上的受体结合会诱导IgD结合因子的形成。
