Research Unit of Population Health, University of Oulu, Oulu, Finland.
Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.
Am J Physiol Heart Circ Physiol. 2024 Jul 1;327(1):H38-H44. doi: 10.1152/ajpheart.00051.2024. Epub 2024 May 17.
Evening chronotype is known to be associated with various chronic diseases and cardiovascular risk factors. Metabolic syndrome is a group of conditions that together raise the risk of coronary heart disease, diabetes, stroke, and other serious health problems. Only a few studies have been published on the association between chronotype and metabolic syndrome in unselected population data, with conflicting results. The aim of this study was to evaluate the association between chronotype and metabolic syndrome at population level by using unselected Northern Finland Birth cohort 1966 (NFBC1966) database. The study population consists of participants with NFBC66 ( = 5,113, 57% female) at the age of 46 yr old. Chronotype was determined with shortened Morningness-Eveningness Questionnaires and expressed as morning (44%), intermediate (44%), and evening types (12%). Metabolic syndrome was determined according to the definition of International Diabetes Federation. One-way ANOVA, Kruskal-Walli's test, and χ tests were used to compare the chronotype groups, followed by logistic regression analysis (adjusted with alcohol consumption, smoking, marital status, level of education, and leisure-time physical activity). In women, the prevalence of metabolic syndrome was statistically significantly higher in the evening type group: 23, 24, and 34% for morning, intermediate, and evening groups, respectively ( < 0.001). In logistic regression analysis, evening chronotype was associated with higher risk of having metabolic syndrome (OR 1.5; CI 95% 1.2 to 2.0). In this population-based birth cohort study, the evening chronotype was independently associated with higher prevalence of metabolic syndrome in women. Only a few studies have been conducted on the association between chronotype and metabolic syndrome in unselected population data, with conflicting results. In this population-based cohort study of 5,113 participants, the evening chronotype associated with metabolic syndrome in women when there was no such association in men. The result supports a previous South Korean population study of 1,620 participants, in which the association was also found in women, but not in men.
夜间型被认为与各种慢性疾病和心血管风险因素有关。代谢综合征是一组病症，这些病症共同增加了患冠心病、糖尿病、中风和其他严重健康问题的风险。只有少数研究发表了关于在未选择的人群数据中，昼夜型与代谢综合征之间的关联，结果存在冲突。本研究旨在使用未经选择的芬兰北部出生队列 1966 年（NFBC1966）数据库评估人群中昼夜型与代谢综合征之间的关联。研究人群由 NFBC66 年龄为 46 岁的参与者组成（=5113 人，57%为女性）。昼夜型通过缩短的 Morningness-Eveningness 问卷确定，并表示为早晨型（44%）、中间型（44%）和夜间型（12%）。代谢综合征根据国际糖尿病联合会的定义确定。单向方差分析、Kruskal-Walli 检验和 χ 检验用于比较昼夜型组，然后进行逻辑回归分析（调整酒精摄入、吸烟、婚姻状况、教育程度和休闲时间体力活动）。在女性中，夜间型组的代谢综合征患病率有统计学意义上的显著升高：分别为 23%、24%和 34%（<0.001）。在逻辑回归分析中，夜间型昼夜型与代谢综合征的风险增加相关（OR 1.5；95%CI 1.2-2.0）。在这项基于人群的出生队列研究中，夜间型昼夜型与女性代谢综合征的患病率升高独立相关。只有少数研究在未经选择的人群数据中研究了昼夜型与代谢综合征之间的关联，结果存在冲突。在这项针对 5113 名参与者的基于人群的队列研究中，夜间型昼夜型与女性代谢综合征相关，而男性则没有这种关联。该结果支持之前对 1620 名参与者的韩国人群研究，该研究也发现了女性与代谢综合征的关联，但在男性中没有发现。
