Hu Ming-Jun, Hu Wen-Wen, Yao Bei, Dong Xiao-Min, Wang Xue-Li, Su Dan, Song Gui-Qi, Zhang Yong-Liang
Department of Health Management Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.
School of Nursing, Bengbu Medical University, Bengbu, Anhui, People's Republic of China.
Nat Sci Sleep. 2025 Aug 27;17:1985-1995. doi: 10.2147/NSS.S540364. eCollection 2025.
Chronotype can be used to describe individual's circadian preference in behavioral and circadian rhythm, representing the preferences for earlier or later sleep times. This study aimed to investigate the association of chronotype with hypertension and metabolic parameters in middle-aged and older adults.
A total of 945 participants were recruited from December 2023 to December 2024 at First Affiliated Hospital of University of Science and Technology of China. Chronotype was determined using the full Morningness-Eveningness Questionnaire, with higher scores indicating preference for morning chronotype. Chronotype was dichotomized at the median score in current cohort, classifying 447 participants as morning chronotypes and 498 as evening chronotypes. Anthropometric measurements and biochemical analyses were also conducted. Multivariable logistic, linear regression, and restricted cubic spline (RCS) analyses were employed to evaluate association between chronotype, metabolic parameters, and hypertension.
After adjustment for covariates, evening chronotype was significantly associated with hypertension risk (OR = 1.60, 95% CI: 1.17-2.17), compared with morning chronotype. The RCS analysis suggested a significant nonlinearity association between chronotype score and hypertension ( for nonlinear = 0.047). Furthermore, higher chronotype score was significantly associated with decreased levels of total cholesterol [TC, β (95% CI): -0.12 (-0.19, -0.04)], low-density lipoprotein-cholesterol [LDL-C, β (95% CI): -0.21 (-0.33, -0.08)] and serum uric acid [SUA, β (95% CI): -0.09 (-0.18, -0.01)], but with increased levels of aspartate aminotransferase [AST, β (95% CI): 0.16 (0.05, 0.27)]. In discrimination model, chronotype was associated with hypertension independently of TC, SUA, alanine transaminase, and alkaline phosphatase, with model's AUC of 0.779 (95% CI: 0.749-0.808).
In middle-aged and older adults, preference for morning chronotype was associated with decreased levels of TC, LDL-C, and SUA, but with increased levels of AST. Moreover, evening chronotype was significantly independently associated with increased risk of hypertension.
昼夜节律类型可用于描述个体在行为和昼夜节律方面的昼夜偏好，代表对早睡或晚睡时间的偏好。本研究旨在调查昼夜节律类型与中老年人群高血压及代谢参数之间的关联。
2023年12月至2024年12月期间，在中国科学技术大学附属第一医院招募了945名参与者。使用完整的晨型-夜型问卷确定昼夜节律类型，得分越高表明越偏好晨型昼夜节律。根据当前队列的中位数得分将昼夜节律类型二分，将447名参与者分类为晨型昼夜节律，498名参与者分类为夜型昼夜节律。还进行了人体测量和生化分析。采用多变量逻辑回归、线性回归和受限立方样条（RCS）分析来评估昼夜节律类型、代谢参数和高血压之间的关联。
在调整协变量后，与晨型昼夜节律相比，夜型昼夜节律与高血压风险显著相关（OR = 1.60，95% CI：1.17 - 2.17）。RCS分析表明昼夜节律得分与高血压之间存在显著的非线性关联（非线性检验P = 0.047）。此外，昼夜节律得分越高，总胆固醇[TC，β（95% CI）：-0.12（-0.19，-0.04）]、低密度脂蛋白胆固醇[LDL-C，β（95% CI）：-
