T细胞急性淋巴细胞白血病：来自印度的60例患者报告。

T-cell acute lymphoblastic leukemia: a report of 60 patients from India.

作者信息

Advani S H, Kamat D M, Rao D N, Gopal R, Nair C N, Saikia T

出版信息

Oncology. 1985;42(5):282-7. doi: 10.1159/000226047.

Abstract

60 patients studied at the Tata Memorial Hospital from January 1976 to December 1982 were diagnosed as having T-cell acute lymphoblastic leukemia (ALL) by nonimmune rosette formation with sheep red blood cells. The analysis revealed a high incidence of mediastinal mass (50%) and extramedullary infiltration at presentation. The majority of patients (62%) presented with a high WBC count (greater than 50,000/mm3). Unipolar acid phosphatase activity was observed in 90% of patients. The remission rate with a combination treatment of adriamycin, vincristine and prednisolone was found to be 95%. Long-term survival was around 30%. More aggressive or innovative treatments will be needed to improve the results in T-cell ALL.

摘要

1976年1月至1982年12月期间在塔塔纪念医院研究的60例患者通过与绵羊红细胞形成非免疫性玫瑰花结被诊断为T细胞急性淋巴细胞白血病（ALL）。分析显示，初诊时纵隔肿块（50%）和髓外浸润的发生率较高。大多数患者（62%）初诊时白细胞计数较高（大于50,000/mm³）。90%的患者观察到单极酸性磷酸酶活性。发现阿霉素、长春新碱和泼尼松龙联合治疗的缓解率为95%。长期生存率约为30%。需要更积极或创新的治疗方法来改善T细胞ALL的治疗结果。