Penchansky L, Whiteside T L, Wollman M R, Albo V C
Med Pediatr Oncol. 1982;10(4):339-48. doi: 10.1002/mpo.2950100404.
Bone marrows of 41 untreated children and adolescents with acute lymphocytic leukemia were studied by combined immunologic and histochemical methods at the time of diagnosis. Eleven were classified as T-cell lymphoblastic leukemias (27%) on the basis of cytochemical stains and E-rosette assay. The patients in this group has low median age of 8 years, relatively low median WBC of 13.4 x 10(3)/cc, 6/11 were female, and only 2/5 males had a mediastinal mass. The girls had a lower median age than boys (7 vs 9 years), none had mediastinal masses or extramedullary involvement, and their survival was greater than 27 months compared to 14 months for the boys (P less than 0.01). All patients were enrolled and treated on the (then) currently active CCSG protocols for ALL. This study emphasizes the fact that not all patients with T-cell ALL have poor prognosis, that sex could be an important factor affecting survival, and that the difference in survival could not be adequately explained by differences in the initial WBC.
采用免疫和组织化学联合方法，对41例未经治疗的急性淋巴细胞白血病儿童和青少年在诊断时的骨髓进行了研究。根据细胞化学染色和E玫瑰花结试验，11例被分类为T细胞淋巴母细胞白血病（27%）。该组患者的中位年龄较低，为8岁，中位白细胞计数相对较低，为13.4×10³/立方厘米，11例中有6例为女性，男性中只有2/5有纵隔肿块。女孩的中位年龄低于男孩（7岁对9岁），无人有纵隔肿块或髓外受累，与男孩的14个月相比，她们的生存期超过27个月（P<0.01）。所有患者均按照（当时）现行的CCSG急性淋巴细胞白血病方案登记并接受治疗。本研究强调了以下事实：并非所有T细胞急性淋巴细胞白血病患者预后都差，性别可能是影响生存的一个重要因素，且生存差异不能完全用初始白细胞的差异来解释。
