Trebenok Z A, Soldatenkov V A, Sorokina N I, Filippovich I V
Radiobiologiia. 1985 Jul-Aug;25(4):521-4.
Hypoxanthine in vitro causes death of thymocytes and concurrent intranucleosome degradation of chromatin. This process is more manifest in a more radiosensitive thymocyte fraction and prevented by protein synthesis inhibitors. The increase in the yield of hypoxanthine after the effect of lympholytic agents of different nature is not the result of cell death. It is assumed that hypoxanthine, formed in the exposed cells, may be an additional cytotoxic factor on reaching a subliminal concentration.
次黄嘌呤在体外可导致胸腺细胞死亡，并同时引起染色质的核小体内降解。这一过程在对辐射更敏感的胸腺细胞亚群中表现得更为明显，且可被蛋白质合成抑制剂所阻止。不同性质的淋巴细胞溶解剂作用后次黄嘌呤产量的增加并非细胞死亡的结果。据推测，暴露细胞中形成的次黄嘌呤在达到阈下浓度时可能是一种额外的细胞毒性因子。
