Fargeas M J, Fioramonti J, Buéno L
Regul Pept. 1985 Jun;11(2):95-103. doi: 10.1016/0167-0115(85)90070-9.
The effects of intracerebroventricular (i.c.v.) administration of calcitonin and PGE2 on intestinal motility and body temperature were examined in conscious rats chronically fitted with intraparietal electrodes in the small intestine, a cannula in a cerebral lateral ventricle and a subcutaneous thermistor probe. Both calcitonin and PGE2 restored the fasted pattern of intestinal motility in fed rats and induced an increase in body temperature. Indomethacin, an inhibitor of the cyclooxygenase with calcium antagonistic properties, and TMB-8, an intracellular calcium antagonist, blocked the effects of calcitonin on intestinal motility and body temperature. Piroxicam, an inhibitor of the cyclooxygenase which does not affect calcium uptake blocked the thermic but not the intestinal effects of calcitonin. TMB-8 but not indomethacin or piroxicam partially blocked the effects of PGE2 on both intestinal motility and body temperature. It is concluded that the central hyperthermic effect of calcitonin is mediated through the formation and the release of prostaglandins whereas the central action of calcitonin on digestive motility results from intracerebral effects on calcium fluxes.
在长期植入小肠壁内电极、脑侧脑室插管和皮下热敏电阻探头的清醒大鼠中，研究了脑室内注射降钙素和前列腺素E2对肠道蠕动和体温的影响。降钙素和前列腺素E2均可使进食大鼠恢复禁食时的肠道蠕动模式，并引起体温升高。具有钙拮抗特性的环氧化酶抑制剂吲哚美辛和细胞内钙拮抗剂TMB - 8可阻断降钙素对肠道蠕动和体温的影响。不影响钙摄取的环氧化酶抑制剂吡罗昔康可阻断降钙素的热效应，但不阻断其对肠道的效应。TMB - 8可部分阻断前列腺素E2对肠道蠕动和体温的影响，而吲哚美辛和吡罗昔康则不能。得出的结论是，降钙素的中枢热效应是通过前列腺素的形成和释放介导的，而降钙素对消化运动的中枢作用是由脑内对钙通量的影响导致的。
