Fargeas M J, Fioramonti J, Bueno L
Peptides. 1985 Nov-Dec;6(6):1167-71. doi: 10.1016/0196-9781(85)90445-0.
The effects of intracerebroventricular (ICV) and intrathecal (IT) administration of calcitonin gene-related peptide (CGRP) on intestinal motility were examined in conscious rats chronically fitted with intraparietal electrodes in the duodeno-jejunum and a cannula in a cerebral lateral ventricle or catheter in the subarachnoid space. ICV administration of CGRP (0.5-10 micrograms) restores the fasted pattern of intestinal motility in fed rats in a dose-related manner. Intrathecal administration of CGRP or calcitonin also induces fasted pattern but after a 30 min delay. These effects persisted after transection of the spinal cord and no change in intestinal motility appeared after intravenous administration of CGRP at a dose effective when given IT. This study suggests that CGRP, as calcitonin, has a neuromodulatory role in the control of intestinal motility at both brain and spinal cord levels.
在长期植入十二指肠 - 空肠壁内电极以及脑侧脑室套管或蛛网膜下腔导管的清醒大鼠中，研究了脑室内（ICV）和鞘内（IT）注射降钙素基因相关肽（CGRP）对肠道运动的影响。脑室内注射CGRP（0.5 - 10微克）以剂量相关的方式恢复了进食大鼠禁食状态下的肠道运动模式。鞘内注射CGRP或降钙素也诱导出禁食状态下的模式，但有30分钟的延迟。脊髓横断后这些作用仍然存在，且静脉注射在鞘内给药有效剂量时的CGRP后，肠道运动没有变化。本研究表明，与降钙素一样，CGRP在脑和脊髓水平对肠道运动的控制中具有神经调节作用。
