Bueno L, Fargeas M J, Fioramonti J, Primi M P
Gastroenterology. 1985 Jun;88(6):1888-94. doi: 10.1016/0016-5085(85)90015-0.
The effect of intracerebroventricular and intravenous administrations of prostaglandin E2 on gastrointestinal motility were investigated in conscious rats and dogs using electrodes and strain gauges, respectively. Injections were performed during the fed state and the motor changes were compared with those after intracerebroventricular administration of calcitonin, neurotensin, and (D-Ala2, Met5) enkephalinamide. Intracerebroventricular administration of prostaglandin E2 (0.5 micrograms) to fed rats restored the migrating myoelectric complex for 67 +/- 16 min. A migrating myoelectric complex-restoring effect was also observed after intracerebroventricular administration of calcitonin (0.02 U) and neurotensin (80 ng). This effect was blocked by previous intracerebroventricular administration of indomethacin (0.25 mg). Administered centrally to dogs but not intravenously at a 10-fold greater dose, prostaglandin E2 (0.1 microgram/kg) reduced (52.8%) the duration of the jejunal postprandial motor state similarly to that observed after intracerebroventricular administration of calcitonin (0.1 U/kg), neurotensin (0.1 microgram/kg), and (D-Ala2, Met5) enkephalinamide (0.1 microgram/kg). These effects of calcitonin and neurotensin were abolished 4 h after an intramuscular injection of indomethacin (2 mg/kg), whereas those of (D-Ala2, Met5) enkephalinamide persisted. These results suggest that (a) prostaglandins act centrally to control the pattern of intestinal motility in both rats and dogs and (b) calcitonin and neurotensin when injected intracerebroventricularly affect the intestinal motor profile probably by stimulating prostaglandin release within the brain.
分别使用电极和应变仪，研究了前列腺素E2脑室注射和静脉注射对清醒大鼠和犬胃肠道运动的影响。在进食状态下进行注射，并将运动变化与脑室注射降钙素、神经降压素和（D-丙氨酸2，甲硫氨酸5）脑啡肽酰胺后的变化进行比较。给进食的大鼠脑室注射前列腺素E2（0.5微克）可使移行性肌电复合波恢复67±16分钟。脑室注射降钙素（0.02单位）和神经降压素（80纳克）后也观察到移行性肌电复合波恢复作用。预先脑室注射吲哚美辛（0.25毫克）可阻断此作用。以10倍大的剂量给犬进行中枢给药而非静脉给药时，前列腺素E2（0.1微克/千克）使空肠餐后运动状态的持续时间缩短了52.8%，这与脑室注射降钙素（0.1单位/千克）、神经降压素（0.1微克/千克）和（D-丙氨酸2，甲硫氨酸5）脑啡肽酰胺（0.1微克/千克）后观察到的情况相似。肌肉注射吲哚美辛（2毫克/千克）4小时后，降钙素和神经降压素的这些作用消失，而（D-丙氨酸2，甲硫氨酸5）脑啡肽酰胺的作用持续存在。这些结果表明：（a）前列腺素在中枢起作用以控制大鼠和犬的肠道运动模式；（b）脑室注射降钙素和神经降压素可能通过刺激脑内前列腺素释放来影响肠道运动情况。
