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深度学习模型在心力衰竭患者生存率精准预测中的应用。

Applications of deep learning models in precision prediction of survival rates for heart failure patients.

出版信息

Technol Health Care. 2024;32(S1):329-337. doi: 10.3233/THC-248029.

DOI:10.3233/THC-248029
PMID:38759059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11191484/
Abstract

BACKGROUND

Heart failure poses a significant challenge in the global health domain, and accurate prediction of mortality is crucial for devising effective treatment plans. In this study, we employed a Seq2Seq model from deep learning, integrating 12 patient features. By finely modeling continuous medical records, we successfully enhanced the accuracy of mortality prediction.

OBJECTIVE

The objective of this research was to leverage the Seq2Seq model in conjunction with patient features for precise mortality prediction in heart failure cases, surpassing the performance of traditional machine learning methods.

METHODS

The study utilized a Seq2Seq model in deep learning, incorporating 12 patient features, to intricately model continuous medical records. The experimental design aimed to compare the performance of Seq2Seq with traditional machine learning methods in predicting mortality rates.

RESULTS

The experimental results demonstrated that the Seq2Seq model outperformed conventional machine learning methods in terms of predictive accuracy. Feature importance analysis provided critical patient risk factors, offering robust support for formulating personalized treatment plans.

CONCLUSIONS

This research sheds light on the significant applications of deep learning, specifically the Seq2Seq model, in enhancing the precision of mortality prediction in heart failure cases. The findings present a valuable direction for the application of deep learning in the medical field and provide crucial insights for future research and clinical practices.

摘要

背景

心力衰竭在全球健康领域构成重大挑战,准确预测死亡率对于制定有效的治疗方案至关重要。在本研究中,我们使用了深度学习的 Seq2Seq 模型,整合了 12 个患者特征。通过精细地对连续的医疗记录进行建模,我们成功提高了死亡率预测的准确性。

目的

本研究旨在利用 Seq2Seq 模型和患者特征,对心力衰竭病例进行精确的死亡率预测,超越传统机器学习方法的性能。

方法

本研究使用深度学习中的 Seq2Seq 模型,整合 12 个患者特征,对连续的医疗记录进行深入建模。实验设计旨在比较 Seq2Seq 与传统机器学习方法在预测死亡率方面的性能。

结果

实验结果表明,Seq2Seq 模型在预测准确性方面优于传统机器学习方法。特征重要性分析提供了关键的患者风险因素,为制定个性化治疗计划提供了有力支持。

结论

本研究揭示了深度学习,特别是 Seq2Seq 模型在提高心力衰竭病例死亡率预测精度方面的重要应用。研究结果为深度学习在医学领域的应用提供了有价值的方向,并为未来的研究和临床实践提供了重要的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f4/11191484/1dafe918abb7/thc-32-thc248029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f4/11191484/f6388e9ed2e6/thc-32-thc248029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f4/11191484/e94761b4ab0b/thc-32-thc248029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f4/11191484/1dafe918abb7/thc-32-thc248029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f4/11191484/f6388e9ed2e6/thc-32-thc248029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f4/11191484/e94761b4ab0b/thc-32-thc248029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49f4/11191484/1dafe918abb7/thc-32-thc248029-g003.jpg

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本文引用的文献

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Machine learning-based in-hospital mortality prediction models for patients with acute coronary syndrome.基于机器学习的急性冠状动脉综合征患者院内死亡率预测模型。
Am J Emerg Med. 2022 Mar;53:127-134. doi: 10.1016/j.ajem.2021.12.070. Epub 2022 Jan 5.
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Epidemiology of Heart Failure: A Contemporary Perspective.心力衰竭的流行病学:当代观点。
Circ Res. 2021 May 14;128(10):1421-1434. doi: 10.1161/CIRCRESAHA.121.318172. Epub 2021 May 13.
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Comparative Analysis on Machine Learning and Deep Learning to Predict Post-Induction Hypotension.
机器学习与深度学习预测诱导后低血压的对比分析。
Sensors (Basel). 2020 Aug 14;20(16):4575. doi: 10.3390/s20164575.
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Interpretable clinical prediction via attention-based neural network.基于注意力的神经网络的可解释临床预测。
BMC Med Inform Decis Mak. 2020 Jul 9;20(Suppl 3):131. doi: 10.1186/s12911-020-1110-7.
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Gated recurrent unit-based heart sound analysis for heart failure screening.基于门控循环单元的心音分析用于心力衰竭筛查。
Biomed Eng Online. 2020 Jan 13;19(1):3. doi: 10.1186/s12938-020-0747-x.
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Risk Prediction in Heart Failure: New Methods, Old Problems.心力衰竭中的风险预测:新方法,老问题。
JACC Heart Fail. 2020 Jan;8(1):22-24. doi: 10.1016/j.jchf.2019.08.015. Epub 2019 Oct 9.
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Personalized medicine for patients with COPD: where are we?慢性阻塞性肺疾病患者的个体化医学:我们在哪里?
Int J Chron Obstruct Pulmon Dis. 2019 Jul 9;14:1465-1484. doi: 10.2147/COPD.S175706. eCollection 2019.
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LSTM Model for Prediction of Heart Failure in Big Data.基于大数据的心力衰竭预测 LSTM 模型
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Early Detection of Heart Failure Using Electronic Health Records: Practical Implications for Time Before Diagnosis, Data Diversity, Data Quantity, and Data Density.利用电子健康记录早期检测心力衰竭:对诊断前时间、数据多样性、数据量和数据密度的实际影响
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Using recurrent neural network models for early detection of heart failure onset.使用循环神经网络模型进行心力衰竭发作的早期检测。
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