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一篇关于“心血管疾病与猴痘之间潜在关系”的文章述评。

A review regarding the article 'The potential relationship between cardiovascular diseases and monkeypox'.

机构信息

Department of Dermatology, Chengdu Qingbaijiang District People's Hospital, Chengdu, Sichuan 610300, China.

Department of Cardiology, Chengdu Qingbaijiang District People's Hospital, Chengdu, Sichuan 610300, China.

出版信息

Curr Probl Cardiol. 2024 Aug;49(8):102649. doi: 10.1016/j.cpcardiol.2024.102649. Epub 2024 May 15.

Abstract

Cardiovascular involvement in the context of viral infections is a well-documented phenomenon, for their potential to induce myocarditis, pericarditis, and other cardiac complications. While monkeypox is predominantly known for its predilection for the skin and mucous membranes, manifesting as characteristic skin lesions, emerging research suggests that the monkeypox virus can also infiltrate endothelial cells, thereby disseminating systemically and potentially impacting various organ systems, including the cardiovascular system. This has led to the identification of several inflammatory conditions, such as myocarditis and pericarditis, which can complicate the clinical course of monkeypox virus infection. Notably, an increase in cardiac biomarkers, often associated with symptoms of chest pain, has been observed in case reports detailing monkeypox-induced myocarditis. From a clinical cardiology perspective, it is imperative to deepen our understanding of monkeypox to better recognize and manage its cardiovascular implications. Conditions like myocarditis, viral pericarditis, heart failure, and arrhythmias have been known to arise, significantly impacting patients' health and quality of life. A thorough comprehension of the intricate pathophysiological mechanisms underlying these cardiovascular manifestations is crucial for enhancing diagnostic accuracy and refining management strategies. The social implications of cardiovascular complications from viral infections are multifaceted, extending beyond direct health concerns to include psychological distress, social stigma, and broader public health considerations. The clinical management of these complications is challenging and necessitates a multidisciplinary approach, often requiring specialized care. The resultant strain on healthcare resources underscores the importance of preparedness and strategic resource allocation to effectively address these complex health issues.

摘要

心血管系统在病毒感染中的受累是一个有据可查的现象,因为病毒感染有可能导致心肌炎、心包炎和其他心脏并发症。虽然猴痘主要以其对皮肤和黏膜的偏好而闻名,表现为特征性的皮肤损伤,但新的研究表明,猴痘病毒也可以渗透到内皮细胞,从而全身扩散,并可能影响包括心血管系统在内的各种器官系统。这导致了几种炎症性疾病的出现,如心肌炎和心包炎,这些疾病可能会使猴痘病毒感染的临床过程复杂化。值得注意的是,在详细描述猴痘引起的心肌炎的病例报告中,观察到心脏生物标志物的增加,通常与胸痛症状相关。从临床心脏病学的角度来看,深入了解猴痘病毒至关重要,以便更好地识别和管理其对心血管系统的影响。已知会出现心肌炎、病毒性心包炎、心力衰竭和心律失常等疾病,这些疾病会严重影响患者的健康和生活质量。深入了解这些心血管表现背后复杂的病理生理机制对于提高诊断准确性和完善管理策略至关重要。心血管并发症对病毒感染的社会影响是多方面的,不仅直接涉及健康问题,还包括心理困扰、社会耻辱感和更广泛的公共卫生考虑因素。这些并发症的临床管理具有挑战性,需要多学科方法,通常需要专门的护理。由此产生的对医疗资源的压力突出了做好准备和战略性资源分配的重要性,以有效应对这些复杂的健康问题。

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