Naylor A M, Ruwe W D, Kohut A F, Veale W L
Brain Res Bull. 1985 Aug;15(2):209-13. doi: 10.1016/0361-9230(85)90138-8.
The antipyretic action of arginine vasopressin (AVP), administered into a lateral cerebral ventricle or directly into the brain tissue via push-pull perfusion, was investigated in conscious New Zealand White rabbits. Administration of AVP into a lateral cerebral ventricle (ICV) was ineffective in reducing an endotoxin-induced fever and did not alter body temperature in the afebrile rabbit. Control push-pull perfusions with the carrier vehicle were without effect on endotoxin fevers or normal body temperature. Perfusion of the vehicle containing AVP provided significant antipyretic activity against both intravenous (IV) and ICV endotoxin without affecting normal body temperature. Both the maximum fever height and the fever index were significantly reduced during AVP perfusion. Tissue sites in which AVP was found to be antipyretic were located in the rostroventral parts of the septal region, at sites similar to those where perfusion of the peptide caused antipyresis in the sheep and rat. These results support the hypothesis that AVP, or a closely related molecule, may modulate fever within the central nervous system.
在清醒的新西兰白兔中，研究了通过侧脑室注射或经推挽式灌注直接注入脑组织的精氨酸加压素（AVP）的解热作用。向侧脑室（ICV）注射AVP对降低内毒素诱导的发热无效，且对未发热兔子的体温无影响。用载体进行的对照推挽式灌注对内毒素发热或正常体温均无影响。含有AVP的载体灌注对静脉注射（IV）和ICV内毒素均具有显著的解热活性，且不影响正常体温。在AVP灌注期间，最大发热高度和发热指数均显著降低。发现AVP具有解热作用的组织部位位于隔区的吻腹侧部分，类似于该肽灌注在绵羊和大鼠中引起解热作用的部位。这些结果支持以下假设：AVP或与之密切相关的分子可能在中枢神经系统内调节发热。
