支持内源性血管加压素在绵羊自然退热中发挥作用的证据。
Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep.
作者信息
Cooper K E, Kasting N W, Lederis K, Veale W L
出版信息
J Physiol. 1979 Oct;295:33-45. doi: 10.1113/jphysiol.1979.sp012953.
Abstract
- The antipyretic effect of arginine vasopressin (AVP) introduced into the brain by push-pull perfusion was investigated in the sheep. 2. Control perfusions with sucrose solutions had no effect on fevers induced by a bacterial endotoxin. Sucrose solutions containing AVP (4.0 microgram/ml.) perfused at 40 microliter./min had significant antipyretic activity, reducing the two peaks of the fever but had no effect on resting body temperature. 3. Loci in which AVP induced antipyresis were limited to the septal region about 2-3 mm anterior to the anterior commissure. 4. The amounts of AVP in perfusates from the septal region correlated negatively with changes in body temperature. 5. AVP administered I.V. did not lower fever. 6. AVP plasma levels correlated negatively with fever magnitude following premature birth induced by dexamethasone.
摘要
- 通过推挽灌注将精氨酸加压素（AVP）注入绵羊脑内，研究其解热作用。2. 用蔗糖溶液进行对照灌注对细菌内毒素引起的发热无影响。以40微升/分钟的速度灌注含AVP（4.0微克/毫升）的蔗糖溶液具有显著的解热活性，可降低发热的两个峰值，但对静息体温无影响。3. AVP诱导解热的位点局限于前连合前方约2 - 3毫米的隔区。4. 来自隔区的灌注液中AVP的量与体温变化呈负相关。5. 静脉注射AVP不能降低发热。6. 在用地塞米松诱导早产之后，血浆AVP水平与发热程度呈负相关。
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