常见可变型低丙种球蛋白血症患者血液中具有树突状形态的低密度细胞缺陷：正常B细胞受刺激后免疫球蛋白产生减少。
Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia: low immunoglobulin production on stimulation of normal B cells.
作者信息
Farrant J, Bryant A E, Lever A M, Edwards A J, Knight S C, Webster A D
出版信息
Clin Exp Immunol. 1985 Jul;61(1):189-94.
Abstract
Low-density cells (LDC) of dendritic morphology from the blood of patients with common variable (late-onset) hypogammaglobulinaemia (CVH) did not induce allogeneic immunoglobulin production by normal B cells unlike LDC from normal blood. When LDC from patients were treated with pokeweed mitogen (PWM), a lower allogeneic secretion of IgM and IgG was induced in normal B cells than that induced by allogeneic normal LDC treated with PWM. B cells from hypogammaglobulinaemic patients were non-responsive to both normal and patient LDC treated with PWM under all conditions tested.
摘要
与正常血液中的低密度细胞（LDC）不同，常见可变型（迟发型）低丙种球蛋白血症（CVH）患者血液中具有树突状形态的低密度细胞（LDC）不会诱导正常B细胞产生同种异体免疫球蛋白。当用商陆有丝分裂原（PWM）处理患者的LDC时，与用PWM处理的同种异体正常LDC相比，正常B细胞中诱导的IgM和IgG同种异体分泌较低。在所有测试条件下，低丙种球蛋白血症患者的B细胞对用PWM处理的正常和患者LDC均无反应。
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