系统性红斑狼疮中的B淋巴细胞活化：血液单核细胞培养物中自发产生针对DNA和环境抗原的IgG抗体。
B lymphocyte activation in systemic lupus erythematosus: spontaneous production of IgG antibodies to DNA and environmental antigens in cultures of blood mononuclear cells.
作者信息
Dar O, Salaman M R, Seifert M H, Isenberg D A
机构信息
Department of Immunology, St. Mary's Hospital Medical School, London, UK.
出版信息
Clin Exp Immunol. 1988 Sep;73(3):430-5.
Abstract
IgG antibodies to DNA, influenza virus haemagglutinin (HA), adenovirus hexon (HX) and mannan from Candida albicans (MN) have been determined in supernatants from 2-day unstimulated cultures of peripheral blood mononuclear cells from SLE patients and controls. Mean values were much higher in the SLE group, with from 20% (MN) to 85% (DNA) of patients giving values above the normal range. Although a significant correlation was observed between anti-DNA and anti-HA production, anti-HX and anti-MN showed no such correlations. The specificity of the ELISA assays was demonstrated by inhibition tests. It is concluded that a selective form of polyclonal activation in SLE results in the production of antibodies to foreign as well as to self antigens.
摘要
已测定了系统性红斑狼疮（SLE）患者和对照组外周血单个核细胞未经刺激的2天培养上清液中针对DNA、流感病毒血凝素（HA）、腺病毒六邻体（HX）和白色念珠菌甘露聚糖（MN）的IgG抗体。SLE组的平均值要高得多，20%（MN）至85%（DNA）的患者数值高于正常范围。虽然观察到抗DNA和抗HA产生之间存在显著相关性，但抗HX和抗MN之间未显示出此类相关性。通过抑制试验证明了酶联免疫吸附测定（ELISA）的特异性。得出的结论是，SLE中一种选择性的多克隆激活形式导致产生针对外来抗原和自身抗原的抗体。
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