在癌症中修复错误剪接。
(G)Patching up mis-splicing in cancer.
机构信息
IMol Polish Academy of Sciences, Warsaw, Poland.
Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, 22184 Lund, Sweden.
出版信息
Trends Biochem Sci. 2024 Jul;49(7):564-566. doi: 10.1016/j.tibs.2024.05.001. Epub 2024 May 17.
Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.
本巴切、皮内达、加尔维斯等人描绘了含有 G-补丁模体的蛋白 GPATCH8 在剪接因子 SF3B1 的致癌驱动突变相关的错误剪接中的重要作用。GPATCH8 与 SF3B1 突变体合作，影响剪接机制。针对 GPATCH8 为 SF3B1 突变型癌症和其他剪接相关疾病提供了治疗机会。
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