早产儿杏仁核体积及其与社会情感能力的关联：横断面和纵向数据

Amygdala volumes and associations with socio-emotional competencies in preterm youth: cross-sectional and longitudinal data.

作者信息

Pereira Camejo Maricé, Escobar Saade Luciana, Liverani Maria Chiara, Fischi-Gomez Elda, Gui Laura, Borradori Tolsa Cristina, Ha-Vinh Leuchter Russia, Hüppi Petra Susan, Siffredi Vanessa

机构信息

Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

SensoriMotor, Affective and Social Development Laboratory, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.

出版信息

Pediatr Res. 2024 Dec;96(7):1868-1877. doi: 10.1038/s41390-024-03227-y. Epub 2024 May 18.

DOI:10.1038/s41390-024-03227-y

PMID:38762662

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11772232/

Abstract

BACKGROUND

Socio-emotional difficulties often result from very preterm (VPT) birth. The amygdala's developmental trajectory, including its nuclei, has been recognized as a significant factor in observed difficulties. This study aims to assess the relationship between amygdala volume and socio-emotional competencies in VPT children and adolescents.

METHODS

Socio-emotional competencies were assessed, and amygdala volumes, including subnuclei, were extracted automatically from structural scans in a cross-sectional cohort of VPT (n = 75) and full-term (FT, n = 41) aged 6-14 years. Group differences in amygdala volumes were assessed using ANCOVA, and associations with socio-emotional competencies were studied using partial least squares correlation (PLSC). In a VPT subgroup, additional longitudinal data with amygdala volumes at term-equivalent age (TEA) were manually extracted, growth rates calculated, and associations with school-age socio-emotional competencies investigated using PLSC.

RESULTS

Using cross-sectional data at school-age, amygdala volumes displayed comparable developmental patterns between the VPT and the FT groups. Greater volumes were associated with more emotional regulation difficulties in VPT and lower affect recognition competencies in FT. In the longitudinal VPT subgroup, no significant associations were found between amygdala volume trajectory and socio-emotional competencies.

CONCLUSION

Although our findings suggest typical amygdala development after VPT birth, further research is necessary to elucidate the developmental trajectory of amygdala and the role of resilience factors.

IMPACT

In our cohort, amygdala volumes, including subnuclei, displayed comparable developmental trajectories between the very preterm and the full-term groups. Higher amygdala volumes at school-age were associated with higher emotional regulation difficulties in the very-preterm born group, and with lower affect recognition abilities in full-term born children and adolescents. In a subgroup of very-preterm children and adolescents followed from birth to school-age, no significant associations were found between amygdala volumes at term-equivalent age and socio-emotional competencies at school-age.

摘要

背景

社会情感方面的困难常常源于极早产（VPT）。杏仁核的发育轨迹，包括其核团，已被认为是导致所观察到的困难的一个重要因素。本研究旨在评估VPT儿童和青少年的杏仁核体积与社会情感能力之间的关系。

方法

对社会情感能力进行评估，并从6至14岁的VPT（n = 75）和足月（FT，n = 41）横断面队列的结构扫描中自动提取包括亚核团在内的杏仁核体积。使用协方差分析评估杏仁核体积的组间差异，并使用偏最小二乘相关（PLSC）研究与社会情感能力的关联。在一个VPT亚组中，手动提取足月等效年龄（TEA）时的杏仁核体积的额外纵向数据，计算生长率，并使用PLSC研究与学龄期社会情感能力的关联。

结果

使用学龄期的横断面数据，VPT组和FT组的杏仁核体积显示出可比的发育模式。体积越大与VPT组中更多的情绪调节困难以及FT组中较低的情感识别能力相关。在纵向VPT亚组中，未发现杏仁核体积轨迹与社会情感能力之间存在显著关联。

结论

尽管我们的研究结果表明VPT出生后杏仁核发育正常，但仍需要进一步研究以阐明杏仁核的发育轨迹以及复原力因素的作用。

影响

在我们的队列中，包括亚核团在内的杏仁核体积在极早产组和足月组之间显示出可比的发育轨迹。学龄期较高的杏仁核体积与极早产出生组中较高的情绪调节困难相关，与足月出生的儿童和青少年中较低的情感识别能力相关。在一个从出生到学龄期随访的极早产儿童和青少年亚组中，未发现足月等效年龄时的杏仁核体积与学龄期社会情感能力之间存在显著关联。