Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Sci Rep. 2021 Oct 6;11(1):19876. doi: 10.1038/s41598-021-98608-2.
Very preterm (VPT) children and adolescents show executive, behavioural and socio-emotional difficulties that persists into adulthood. This study aims to assess the effectiveness of a mindfulness-based intervention (MBI) in improving these competencies in VPT young adolescents using a randomised controlled trial design. 56 young adolescents aged 10-14 years, born before 32 gestational weeks, were randomly assigned to an "intervention" or a "waiting" group and completed an 8-week MBI in a cross-over design. Executive, behavioural and socio-emotional competencies were assessed at three different time points via parent and self-reported questionnaires, neuropsychological testing and computerised tasks. The data were analysed using an intention-to-treat approach with linear regression modelling. Our findings show a beneficial effect of MBI on executive, behavioural and socio-emotional competencies in VPT young adolescents measured by parent questionnaires. Increased executive competencies were also observed on computerised task with enhanced speed of processing after MBI. Two subgroups of participants were created based on measures of prematurity, which revealed increased long-term benefits in the moderate-risk that were not observed in the high-risk subgroups of VPT young adolescents. MBI seems a valuable tool for reducing detrimental consequences of prematurity in young adolescents, especially regarding executive, behavioural and socio-emotional difficulties.Clinical Trial Registration ClinicalTrials, NCT04638101. Registered 20 November 2020-Retrospectively registered, https://clinicaltrials.gov/show/NCT04638101 .
极早产儿（VPT）儿童和青少年表现出执行、行为和社会情感方面的困难，这些问题会持续到成年。本研究旨在评估基于正念的干预（MBI）在使用随机对照试验设计改善 VPT 青少年这些能力方面的有效性。56 名年龄在 10-14 岁、胎龄小于 32 周的青少年被随机分配到“干预”或“等待”组，并以交叉设计完成 8 周的 MBI。通过父母和自我报告的问卷、神经心理学测试和计算机任务，在三个不同时间点评估执行、行为和社会情感能力。使用意向治疗方法和线性回归模型分析数据。我们的研究结果表明，MBI 对 VPT 青少年的执行、行为和社会情感能力有有益的影响，这是通过父母问卷测量的。在 MBI 后，计算机任务的执行能力也有所提高，处理速度加快。根据早产程度的测量结果，创建了两个参与者亚组，结果表明中危组的长期受益增加，而 VPT 青少年的高危组则没有观察到这种情况。MBI 似乎是一种减少青少年早产不利后果的有价值的工具，特别是在执行、行为和社会情感困难方面。临床试验注册ClinicalTrials，NCT04638101。于 2020 年 11 月 20 日注册-回顾性注册，https://clinicaltrials.gov/show/NCT04638101。
