中性粒细胞弹性蛋白酶（NEUT-RI）是 NETosis 的替代标志物，在具有强 IgM 抗磷脂抗体的患者中水平较低。
NEUT-RI, a surrogate marker of NETosis is lower in patients with strong IgM antiphospholipid antibodies.
机构信息
Department of Hematology, Nîmes University Hospital, Place du Professeur Robert Debré, Nîmes, 30029, France.
Desbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, University of Montpellier, Montpellier, France.
出版信息
J Thromb Thrombolysis. 2024 Aug;57(6):1051-1055. doi: 10.1007/s11239-024-03001-1. Epub 2024 May 18.
BACKGROUND
Antiphospholipid antibody syndrome (APS) is an acquired autoimmune disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy complications. Recently, thrombotic APS was linked to increased neutrophil extracellular traps (NET) formation, suggesting an association between NETs and the severity of APS-related thrombosis.
METHODS
We performed a retrospective study on patients tested for presence of antiphospholipid antibodies (990 negative and 374 positive) to evaluate the association between the neutrophil activation state, estimated by the neutrophil reactive index (NEU-RI), a parameter routinely available from some haematology analysers, and antiphospholipid antibodies.
RESULTS
We do not observe a difference in NEU-RI values between positive and negative patients globally. However, interestingly, we highlight an association between high titers of IgM and low NEU-RI values indicating a lower neutrophil activation.
CONCLUSION
Our data are in line with the recent questioning about the putative clinical consistency of positive solid-phase aPL IgM.
背景
抗磷脂抗体综合征（APS）是一种获得性自身免疫性疾病，其特征为反复发生静脉或动脉血栓形成和/或妊娠并发症。最近，血栓性 APS 与中性粒细胞胞外诱捕网（NET）形成增加有关，这表明 NETs 与 APS 相关血栓形成的严重程度之间存在关联。
方法
我们对检测抗磷脂抗体（990 例阴性和 374 例阳性）的患者进行了回顾性研究，以评估中性粒细胞激活状态与抗磷脂抗体之间的关系，该激活状态由中性粒细胞反应指数（NEU-RI）估计，这是一些血液分析仪常规提供的参数。
结果
我们未观察到总体上阳性患者和阴性患者之间的 NEU-RI 值存在差异。然而，有趣的是，我们强调了 IgM 高滴度与低 NEU-RI 值之间的关联，表明中性粒细胞的激活程度较低。
结论
我们的数据与最近对固相 aPL IgM 的潜在临床一致性的质疑相一致。
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