Laboratory of Epidemiology of Chronic and Neurological Diseases, Lemacen, Cotonou, Benin.
Department of Visceral Surgery, National Teaching Hospital-Hubert Koutoukou Maga, CNHU-HKM, Cotonou, Benin.
BMC Womens Health. 2024 May 18;24(1):295. doi: 10.1186/s12905-024-03114-y.
In Benin, a country in West Africa, breast cancer is the leading cancer in women, both in terms of incidence and mortality. However, evidence on the mortality of breast cancer and its associated factors is lacking in this country. Our aim was to describe and analyze the clinical, histopathological, and prognostic aspects of breast cancer in Benin.
A descriptive and analytical study was carried out at the CNHU-HKM and the CHU-MEL, two major tertiary referral hospitals for breast cancer management located in Cotonou, the capital city of Benin. All breast cancer medical records with histological evidence and immunohistochemistry studies were retrospectively collected between January 1, 2014, and September 30, 2020, in these two tertiary referral hospitals and analyzed in the current study.
Finally, 319 medical records were included. The mean age at diagnosis was 48.74 years. The tumors were most frequently classified as T4 (47.6%) with lymph node involvement N2 (34.5%), and metastases were clinically noted in 21.9% of cases. Stage was reported in the medical records of 284 patients. Tumors were diagnosed at very late AJCC stages: stage III (47.5%) and stage IV (24.7%). Grades SBR 2 (49.2%) and SBR 3 (32.6%) were the most frequent grades. Triple-negative breast cancer (31.3%) was the most common molecular type. The overall 5-year survival was 48.49%. In multivariable analysis, the poor prognostic factors were lymph node invasion (HR = 2.63; p = 0.026; CI: [1.12, 6.17]), the presence of metastasis (HR = 3.64; p < 0.001); CI: [2.36, 5.62] and the immunohistochemical profile (HR = 1.29; p < 0.001; CI: [1.13, 1.48]).
Breast cancer in Beninese is predominant in young adults and is often diagnosed at a late stage. The survival of breast cancer patients in Benin can be improved by enhancing early diagnosis and multidisciplinary management.
在西非国家贝宁，乳腺癌无论在发病率还是死亡率方面均居女性癌症之首。然而，该国在乳腺癌死亡率及其相关因素方面的证据尚缺乏。我们旨在描述和分析贝宁乳腺癌的临床、组织病理学和预后方面。
在 CNHU-HKM 和 CHU-MEL 这两家位于贝宁首都科托努的主要乳腺癌三级转诊医院进行了一项描述性和分析性研究。在这两家三级转诊医院，回顾性收集了 2014 年 1 月 1 日至 2020 年 9 月 30 日之间所有具有组织学证据和免疫组织化学研究的乳腺癌病历，并对其进行了分析。
最终纳入了 319 份病历。诊断时的平均年龄为 48.74 岁。肿瘤最常被归类为 T4（47.6%），淋巴结受累 N2（34.5%），21.9%的病例有临床转移。284 名患者的病历中有分期报告。肿瘤被诊断为非常晚期的 AJCC 分期：III 期（47.5%）和 IV 期（24.7%）。SBR 2 级（49.2%）和 SBR 3 级（32.6%）是最常见的分级。三阴性乳腺癌（31.3%）是最常见的分子类型。总体 5 年生存率为 48.49%。在多变量分析中，不良预后因素包括淋巴结侵犯（HR=2.63；p=0.026；CI：[1.12, 6.17]）、转移存在（HR=3.64；p<0.001；CI：[2.36, 5.62]）和免疫组化特征（HR=1.29；p<0.001；CI：[1.13, 1.48]）。
贝宁的乳腺癌主要发生在年轻女性中，且常被诊断为晚期。通过加强早期诊断和多学科管理，可提高贝宁乳腺癌患者的生存率。
