Department of Cardiology, Cardiovascular Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, China; Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China; Xiamen Municipal Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China; Xiamen Research Center for Eye Diseases and Key Laboratory of Ophthalmology, Xiamen, Fujian, China.
Ecotoxicol Environ Saf. 2024 Jul 1;279:116459. doi: 10.1016/j.ecoenv.2024.116459. Epub 2024 May 18.
Diabetic retinopathy (DR), one of the most common microvascular complications of diabetes mellitus (DM), is a major contributor of vision impairment and blindness worldwide. Studies have shown that air pollution exposure is adversely associated with DM. However, evidence is scarce regarding how air pollution exposure affects DR. This study aimed to investigate the association between ambient air pollution exposure and DR risk.
The study population was based on the Fujian Eye Study (FJES), an ophthalmologic, epidemiologic survey investigating the eye health condition of residents in Fujian Province from 2018 to 2019. Daily average concentrations of ambient air pollutants (PM, PM, SO, NO, and O) were acquired from a high-resolution air quality dataset in China from 2013 to 2018. We used a logistic regression model to examine the associations between DR risk and long-term air pollution at various exposure windows.
A total of 2405 out of the 8211 participants were diagnosed with diabetes, among whom 183 had DR. Ambient air pollution, especially particulate matter (i.e., PM and PM) and NO were positively associated with DR prevalence among all the study subjects. Ambient SO and O concentrations were not associated with DR prevalence. PM and NO seemed to be borderline significantly associated with increased prevalence of DR in subjects with DM, especially under the model adjusted for sex, age, BMI, SBP, and DBP.
These findings showed that long-term exposure to ambient particulate matter and NO was associated with a high DR risk in Fujian province, where ambient air pollution is relatively low.
糖尿病视网膜病变（DR）是糖尿病（DM）最常见的微血管并发症之一，是全球视力损害和失明的主要原因。研究表明，空气污染暴露与 DM 呈负相关。然而，关于空气污染暴露如何影响 DR 的证据很少。本研究旨在探讨环境空气污染暴露与 DR 风险之间的关系。
研究人群基于福建眼病研究（FJES），这是一项眼科流行病学调查，旨在研究 2018 年至 2019 年福建省居民的眼部健康状况。从中国的高分辨率空气质量数据集获取 2013 年至 2018 年的每日平均环境空气污染物（PM、PM、SO、NO 和 O）浓度。我们使用逻辑回归模型来研究不同暴露窗口下 DR 风险与长期空气污染之间的关系。
在 8211 名参与者中，共有 2405 名被诊断患有糖尿病，其中 183 名患有 DR。环境空气污染，特别是颗粒物（即 PM 和 PM）和 NO 与所有研究对象的 DR 患病率呈正相关。SO 和 O 浓度与 DR 患病率无关。PM 和 NO 似乎与 DM 患者 DR 患病率的增加呈显著相关，尤其是在调整了性别、年龄、BMI、SBP 和 DBP 的模型中。
这些发现表明，长期暴露于环境颗粒物和 NO 与福建省 DR 风险增加有关，而福建省的空气污染相对较低。
