Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China.
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Medical University, Tianjin 300070, China.
Environ Int. 2021 Sep;154:106568. doi: 10.1016/j.envint.2021.106568. Epub 2021 Apr 17.
While the relationship between ambient air pollution and diabetes mellitus has recently been reported, data on the association between fine particulate matter (PM) and diabetic complications are limited, especially in microvascular diseases such as diabetic retinopathy.
To investigate the associations between long-term exposure to PM and the prevalence of diabetic retinopathy in adult diabetic patients in rural China.
The study population was based on the Rural Epidemiology for Glaucoma in China (REG-China), a national cross-sectional survey conducted in rural China. This analysis selected diabetic patients with or without diabetic retinopathy. A satellite-based spatiotemporal model was used to estimate personal PM exposure. Logistic regression models were used to investigate the effect of long-term PM exposure on diabetic retinopathy.
The analysis included 3111 diabetic participants, 329 of whom were diagnosed with diabetic retinopathy. The median level of exposure to PM from 2000 to2016 was 59.9 μg/m. For each 10 μg/m increase in PM, the adjusted odds ratio (95% confidence interval) for diabetic retinopathy was 1.41 (1.27, 1.57). In subgroup analyses, the effect of PM on diabetic retinopathy was significantly stronger in participants who self-reported alcohol consumption.
These findings suggest that long-term exposure to high PM was associated with the risk of diabetic retinopathy among diabetic patients in rural China.
尽管最近有报道称环境空气污染与糖尿病之间存在关联，但关于细颗粒物（PM）与糖尿病并发症之间的关系的数据有限，尤其是在糖尿病视网膜病变等微血管疾病方面。
调查长期暴露于 PM 与中国农村成年糖尿病患者中糖尿病视网膜病变患病率之间的关系。
该研究人群基于中国农村青光眼农村流行病学研究（REG-China），这是在中国农村进行的一项全国性横断面调查。本分析选择了有或没有糖尿病视网膜病变的糖尿病患者。基于卫星的时空模型用于估计个人 PM 暴露。使用逻辑回归模型调查长期 PM 暴露对糖尿病视网膜病变的影响。
分析包括 3111 名糖尿病患者，其中 329 名被诊断为糖尿病视网膜病变。2000 年至 2016 年期间暴露于 PM 的中位数水平为 59.9μg/m。PM 每增加 10μg/m，糖尿病视网膜病变的调整后比值比（95%置信区间）为 1.41（1.27，1.57）。在亚组分析中，PM 对糖尿病视网膜病变的影响在自我报告饮酒的参与者中更为明显。
这些发现表明，长期暴露于高 PM 与中国农村糖尿病患者发生糖尿病视网膜病变的风险相关。
