Zhou Lang, Chen Faju, Yang Lishou, Peng Mei, Pan Xiong, Lou Huayong, Yang Juan, Yang Xiaosheng, Li Qiji
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Natural Products Research Center of Guizhou Province, Guiyang 550014, China.
Int J Mol Sci. 2024 Nov 26;25(23):12693. doi: 10.3390/ijms252312693.
In the ongoing search for new vicinal diol natural products, four new (Migaones A-D, -) and four known (-) vicinal diol sesquiterpenoids were isolated from the branches and leaves of . Their structures were unequivocally determined by comprehensive spectroscopic analyses (HRESIMS, 1D, and 2D NMR), single-crystal X-ray diffraction, electronic circular dichroism calculations, and comparison with existing literature data. All compounds isolated from possess vicinal diol structural units except compound . The newly isolated compounds (-) were evaluated for their neuroprotective activity using the PC12 cell injury model induced by -methyl-daspartate acid (NMDA) and compounds - showing moderate neuroprotective activity against NMDA-induced neurotoxicity. Furthermore, molecular docking studies indicated that the most active compound binds to the active site of the NMDA receptor via hydrogen bonds and hydrophobic interactions.
在持续寻找新的邻二醇天然产物的过程中，从[植物名称]的枝叶中分离出了四种新的（米高酮A - D）和四种已知的（[已知化合物名称]）邻二醇倍半萜类化合物。通过综合光谱分析（高分辨电喷雾电离质谱、一维和二维核磁共振）、单晶X射线衍射、电子圆二色性计算以及与现有文献数据对比，明确确定了它们的结构。从[植物名称]中分离出的所有化合物除了[化合物名称]外都具有邻二醇结构单元。使用由N - 甲基 - D - 天冬氨酸（NMDA）诱导的PC12细胞损伤模型，对新分离出的化合物（[新化合物名称]）进行了神经保护活性评估，化合物[活性化合物编号]对NMDA诱导的神经毒性表现出中等程度的神经保护活性。此外，分子对接研究表明，活性最高的化合物[活性最高化合物编号]通过氢键和疏水相互作用与NMDA受体的活性位点结合。
