Nano/micro-plastic, an invisible threat getting into the brain.

Due to weather and working/operational conditions, plastic degradation produces toxic and non-biodegradable nano and microplastics (N/M-Ps, ranging from 10 nm to 5 mm), and over time these N/M-Ps have integrated with the human cycle through ingestion and inhalation. These N/M-Ps, as serious emerging pollutants, are causing considerable adverse health issues due to up-taken by the cells, tissue, and organs, including the brain. It has been proven that N/M-Ps can cross the blood-brain barrier (via olfactory and blood vessels) and affect the secretion of neuroinflammatory (cytokine and chemokine), transporters, and receptor markers. Neurotoxicity, neuroinflammation, and brain injury, which may result in such scenarios are a serious concern and may cause brain disorders. However, the related pathways and pathogenesis are not well-explored but are the focus of upcoming emerging research. Therefore, as a focus of this editorial, well-organized multidisciplinary research is required to explore associated pathways and pathogenesis, leading to brain mapping and nano-enabled therapeutics in acute and chronic N/M - Ps exposure.