Holm S, Andersen A R, Vorstrup S, Lassen N A, Paulson O B, Holmes R A
J Nucl Med. 1985 Oct;26(10):1129-34.
The lipophilic 99mTc-labeled oxime propylene amine oxime (PnAO) should, according to recent reports behave like 133Xe in the human brain. This study compares SPECT images of the two tracers in six subjects: four stroke cases, one transitory ischemic attack case and one normal subject. Technetium-99m PnAO was injected i.v. as a bolus of 15 to 25 mCi. The distribution was followed over 10-sec intervals using a highly sensitive, rapidly rotating SPECT (Tomomatic 64) and compared to 133Xe flow maps. Upon arrival of the PnAO bolus to the brain, a high uptake was found in brain tissue with high cerebral blood flow followed by rapid washout. In the stroke cases, low flow areas were equally well visualized by both tracers. Two dissimilarities were seen in the initial pictures: PnAO visualized the cerebral veins and showed a lesser contrast of gray:white matter uptake. The results suggest that PnAO has a high yet incomplete brain extraction yielding a flow dominated initial distribution with limitations mentioned.
根据最近的报告，亲脂性的99mTc标记的肟丙二胺肟（PnAO）在人脑内的表现应与133Xe相似。本研究比较了6名受试者（4例中风患者、1例短暂性脑缺血发作患者和1例正常受试者）使用这两种示踪剂的单光子发射计算机断层扫描（SPECT）图像。静脉推注15至25毫居里的99mTc PnAO。使用高灵敏度、快速旋转的SPECT（Tomomatic 64）每隔10秒追踪一次其分布情况，并与133Xe血流图进行比较。PnAO团注到达脑部后，在脑血流量高的脑组织中发现高摄取，随后快速清除。在中风病例中，两种示踪剂对低血流区域的显影效果相同。在初始图像中发现两个不同之处：PnAO显影了脑静脉，且灰质/白质摄取对比度较低。结果表明，PnAO对脑的摄取率高但不完全，产生了以血流为主导的初始分布，存在上述局限性。
