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阿尔茨海默病的睡眠功能连接、过度兴奋和认知。

Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease.

机构信息

Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

出版信息

Alzheimers Dement. 2024 Jun;20(6):4234-4249. doi: 10.1002/alz.13861. Epub 2024 May 19.

DOI:10.1002/alz.13861
PMID:38764252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11180941/
Abstract

INTRODUCTION

Sleep disturbances are common in Alzheimer's disease (AD) and may reflect pathologic changes in brain networks. To date, no studies have examined changes in sleep functional connectivity (FC) in AD or their relationship with network hyperexcitability and cognition.

METHODS

We assessed electroencephalogram (EEG) sleep FC in 33 healthy controls, 36 individuals with AD without epilepsy, and 14 individuals with AD and epilepsy.

RESULTS

AD participants showed increased gamma connectivity in stage 2 sleep (N2), which was associated with longitudinal cognitive decline. Network hyperexcitability in AD was associated with a distinct sleep connectivity signature, characterized by decreased N2 delta connectivity and reversal of several connectivity changes associated with AD. Machine learning algorithms using sleep connectivity features accurately distinguished diagnostic groups and identified "fast cognitive decliners" among study participants who had AD.

DISCUSSION

Our findings reveal changes in sleep functional networks associated with cognitive decline in AD and may have implications for disease monitoring and therapeutic development.

HIGHLIGHTS

Brain functional connectivity (FC) in Alzheimer's disease is altered during sleep. Sleep FC measures correlate with cognitive decline in AD. Network hyperexcitability in AD has a distinct sleep connectivity signature.

摘要

简介

睡眠障碍在阿尔茨海默病（AD）中很常见，可能反映了大脑网络的病理变化。迄今为止，尚无研究探讨 AD 患者睡眠功能连接（FC）的变化及其与网络过度兴奋和认知的关系。

方法

我们评估了 33 名健康对照者、36 名无癫痫的 AD 患者和 14 名 AD 合并癫痫患者的脑电图（EEG）睡眠 FC。

结果

AD 参与者在 N2 期表现出伽马连接增加，这与纵向认知下降有关。AD 中的网络过度兴奋与睡眠连接的特征性改变有关，其特征是 N2 期的 delta 连接减少，以及与 AD 相关的几种连接变化的逆转。使用睡眠连接特征的机器学习算法可以准确地区分诊断组，并识别出具有 AD 的研究参与者中的“快速认知衰退者”。

讨论

我们的研究结果揭示了与 AD 认知下降相关的睡眠功能网络变化，可能对疾病监测和治疗开发具有重要意义。

重点

AD 患者大脑功能连接（FC）在睡眠期间发生改变。睡眠 FC 测量值与 AD 认知下降相关。AD 中的网络过度兴奋具有独特的睡眠连接特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/989d58e444a1/ALZ-20-4234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/ad48a69907bf/ALZ-20-4234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/fcb731cb07e3/ALZ-20-4234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/86b4b3565b36/ALZ-20-4234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/6060c6816080/ALZ-20-4234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/989d58e444a1/ALZ-20-4234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/ad48a69907bf/ALZ-20-4234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/fcb731cb07e3/ALZ-20-4234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/86b4b3565b36/ALZ-20-4234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/6060c6816080/ALZ-20-4234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf6/11180941/989d58e444a1/ALZ-20-4234-g003.jpg

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J Alzheimers Dis. 2023;91(4):1557-1572. doi: 10.3233/JAD-221152.
3
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5
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