类风湿关节炎中备解素因子B（Bf）的基因变异
Genetic variants of properdin factor B (Bf) in rheumatoid arthritis.
作者信息
Dyer P, Grennan D M, Dodds W, Walton K, Read A, Klimiuk P, Clague R, Harris R
出版信息
J Rheumatol. 1985 Jun;12(3):456-7.
Properdin factor B (Bf) phenotyping was carried out in 392 patients with rheumatoid arthritis (RA) and in 360 controls. In RA there were increased frequencies of both the BfS gene (83 vs 78%; pc = 0.0003) and the BfSS genotype 73 vs 61%; pc = 0.0002) and reduced frequencies of the BfF1 gene (0.5 vs 2.2%; pc = 0.03) and the BfFS genotype (20 vs 29%; pc = 0.0007). The frequencies of BfS in DR4 positive and DR4 negative RA were similar so that the findings were not accounted for by linkage disequilibrium between DR4 and BfS.
对392例类风湿性关节炎（RA）患者和360名对照者进行了备解素因子B（Bf）表型分析。在类风湿性关节炎患者中，BfS基因（83%对78%；pc = 0.0003）和BfSS基因型（73%对61%；pc = 0.0002）的频率均升高，而BfF1基因（0.5%对2.2%；pc = 0.03）和BfFS基因型（20%对29%；pc = 0.oooo7）的频率降低。DR4阳性和DR4阴性类风湿性关节炎患者中BfS的频率相似，因此这些发现不能用DR4与BfS之间的连锁不平衡来解释。
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