类风湿关节炎患者的HLA - DMA和DMB基因分型
HLA-DMA and DMB genotyping in patients with rheumatoid arthritis.
作者信息
Yen J H, Chen C J, Tsai W C, Tsai J J, Chang J G, Liu H W
机构信息
Department of Internal Medicine, Kaohsiung Medical College, Kaohsiung City, Taiwan.
出版信息
J Rheumatol. 1997 Mar;24(3):442-4.
OBJECTIVE
To investigate the relation of HLA-DMA and DMB alleles to the development of rheumatoid arthritis (RA).
METHODS
We studied HLA-DMA and DMB alleles in 153 patients with RA and 138 healthy controls using the amplification created restriction site method and digestion with restriction enzymes.
RESULTS
There was no significant difference in frequencies of HLA-DMA and DMB alleles between patients with RA and controls. The HLA-DMA and DMB alleles were not related to extraarticular involvement, seropositivity for rheumatoid factor, or bone erosion. There was also no significant difference in frequencies of HLA-DMA and DMB alleles among DR4-positive and DR4-negative patients and controls.
CONCLUSION
HLA-DMA and DMB do not appear to be associated with the pathogenesis of RA.
目的
研究人类白细胞抗原DMA（HLA - DMA）和DMB等位基因与类风湿关节炎（RA）发病的关系。
方法
我们采用扩增产生限制酶切位点法及限制酶消化法，对153例RA患者和138名健康对照者的HLA - DMA和DMB等位基因进行了研究。
结果
RA患者与对照者之间HLA - DMA和DMB等位基因频率无显著差异。HLA - DMA和DMB等位基因与关节外受累、类风湿因子血清阳性或骨侵蚀无关。DR4阳性和DR4阴性患者及对照者之间HLA - DMA和DMB等位基因频率也无显著差异。
结论
HLA - DMA和DMB似乎与RA的发病机制无关。
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