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卵巢癌中花生四烯酸代谢的失调

The deregulation of arachidonic acid metabolism in ovarian cancer.

作者信息

Xia Qiuyi, Gao Wen, Yang Jintao, Xing Zhifang, Ji Zhaodong

机构信息

Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.

出版信息

Front Oncol. 2024 May 2;14:1381894. doi: 10.3389/fonc.2024.1381894. eCollection 2024.

DOI:10.3389/fonc.2024.1381894
PMID:38764576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11100328/
Abstract

Arachidonic acid (AA) is a crucial polyunsaturated fatty acid in the human body, metabolized through the pathways of COX, LOX, and cytochrome P450 oxidase to generate various metabolites. Recent studies have indicated that AA and its metabolites play significant regulatory roles in the onset and progression of ovarian cancer. This article examines the recent research advancements on the correlation between AA metabolites and ovarian cancer, both domestically and internationally, suggesting their potential use as biological markers for early diagnosis, targeted therapy, and prognosis monitoring.

摘要

花生四烯酸（AA）是人体中一种关键的多不饱和脂肪酸，通过环氧化酶（COX）、脂氧合酶（LOX）和细胞色素P450氧化酶途径进行代谢，产生各种代谢产物。最近的研究表明，AA及其代谢产物在卵巢癌的发生和发展中发挥着重要的调节作用。本文综述了国内外关于AA代谢产物与卵巢癌相关性的最新研究进展，提示它们有可能作为早期诊断、靶向治疗和预后监测的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/3d4fd313659f/fonc-14-1381894-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/ad6cc4ca42b0/fonc-14-1381894-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/f94a82b76695/fonc-14-1381894-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/8a1736d3dc4d/fonc-14-1381894-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/b5c141a2bb79/fonc-14-1381894-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/3d4fd313659f/fonc-14-1381894-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/ad6cc4ca42b0/fonc-14-1381894-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/f94a82b76695/fonc-14-1381894-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/8a1736d3dc4d/fonc-14-1381894-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/b5c141a2bb79/fonc-14-1381894-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1b/11100328/3d4fd313659f/fonc-14-1381894-g005.jpg

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