花生四烯酸代谢产物对心血管健康和疾病的影响。
Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease.
机构信息
Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade, Taipa, Macau 999078, China.
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
出版信息
Int J Mol Sci. 2021 Nov 6;22(21):12029. doi: 10.3390/ijms222112029.
Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes, and lipid oxygenase (LOX) pathways to regulate complex cardiovascular function under physiological and pathological conditions. Various AA metabolites include prostaglandins, prostacyclin, thromboxanes, hydroxyeicosatetraenoic acids, leukotrienes, lipoxins, and epoxyeicosatrienoic acids. The AA metabolites play important and differential roles in the modulation of vascular tone, and cardiovascular complications including atherosclerosis, hypertension, and myocardial infarction upon actions to different receptors and vascular beds. This article reviews the roles of AA metabolism in cardiovascular health and disease as well as their potential therapeutic implication.
花生四烯酸（AA）是一种必需脂肪酸，它从细胞膜中的磷脂释放出来，并通过环氧化酶（COX）、细胞色素 P450（CYP）酶和脂质氧化酶（LOX）途径代谢，以在生理和病理条件下调节复杂的心血管功能。各种 AA 代谢物包括前列腺素、前列环素、血栓素、羟二十碳四烯酸、白三烯、脂氧素和环氧二十碳三烯酸。AA 代谢物在调节血管张力方面发挥着重要且不同的作用，在不同受体和血管床的作用下，包括动脉粥样硬化、高血压和心肌梗死在内的心血管并发症。本文综述了 AA 代谢在心血管健康和疾病中的作用及其潜在的治疗意义。
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