An Gary, Cockrell Chase
Department of Surgery, University of Vermont Larner College of Medicine.
ArXiv. 2024 Jun 16:arXiv:2405.05301v2.
On December 15, 2023, The National Academies of Sciences, Engineering and Medicine (NASEM) released a report entitled: "Foundational Research Gaps and Future Directions for Digital Twins." The ostensible purpose of this report was to bring some structure to the burgeoning field of digital twins by providing a working definition and a series of research challenges that need to be addressed to allow this technology to fulfill its full potential. In the work presented herein we focus on five specific findings from the NASEM Report: 1) definition of a Digital Twin, 2) using "fit-for-purpose" guidance, 3) developing novel approaches to Verification, Validation and Uncertainty Quantification (VVUQ) of Digital Twins, 4) incorporating control as an explicit purpose for a Digital Twin and 5) using a Digital Twin to guide data collection and sensor development, and describe how these findings are addressed through the design specifications for a Critical Illness Digital Twin (CIDT) aimed at curing sepsis.
2023年12月15日，美国国家科学院、工程院和医学院（NASEM）发布了一份题为《数字孪生的基础研究差距与未来方向》的报告。该报告表面上的目的是通过提供一个实用定义以及一系列为使这项技术充分发挥潜力而需要应对的研究挑战，为新兴的数字孪生领域带来一定的架构。在本文所展示的工作中，我们聚焦于NASEM报告中的五项具体发现：1）数字孪生的定义；2）采用“适用目的”指南；3）开发数字孪生验证、确认与不确定性量化（VVUQ）的新方法；4）将控制纳入数字孪生的明确目的；5）利用数字孪生指导数据收集和传感器开发，并描述如何通过旨在治疗败血症的危重症数字孪生（CIDT）的设计规范来解决这些发现。
