Zhang Lili, Zhang Yunshu, Guo Wentao, Ma Qi, Zhang Feng, Li Keqing, Yi Qizhong
The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.
Hebei Provincial Mental Health Center, Baoding, Hebei Province, People's Republic of China.
Neuropsychiatr Dis Treat. 2024 May 14;20:1011-1024. doi: 10.2147/NDT.S460429. eCollection 2024.
Depressive disorder is a mental health disorder with complicated etiopathogenesis. Environmental stress and neurodevelopment combined with other factors contribute to the occurrence of depression. Especially for the depressive disorder with chronic negative stress, it has characteristics of recurrence and poor curative effect because of unclear mechanism. Here, we investigated the hippocampal structures and functional connectivity (FC) according to resting-state functional magnetic resonance imaging in patients with depression who underwent chronic negative stress.
A total of 65 patients with depression (34 underwent chronic negative stress and 31 non-underwent chronic negative stress) and 30 healthy controls who did not undergo chronic negative stress were included in the study. The volumes of hippocampal subfields, seed-based FCs between hippocampus and the whole brain voxels, and ROI-wise-based FC between hippocampal subfields were compared among the three groups.
In the patients with depression who underwent chronic negative stress, the volumes of right_GC-ML-DG-head, right_CA4-head and right_CA3-head increased, FCs between Temporal_Mid_R, Precuneus_R, Frontal_Sup_R, Temporal_Sup_R, Angular_L, Frontal_Inf_Tri_R, Supp_Motor_Area_R, Precentral_L and hippocampus increased, and FCs between parasubiculum and CA3, and presubiculum and CA1 decreased. When compared to the patients who did not undergo chronic negative stress, the patients who underwent chronic negative stress had larger volumes of right_GC-ML-DG-head and right_CA3-head, higher FCs between Frontal_Sup_R, Frontal_Inf_Tri_R and hippocampus, and lower FCs between presubiculum and CA1.
The depression underwent chronic negative stress may experience disrupted hippocampal structures and functional connectivity. It may be one of potential depressive disorder subtypes.
抑郁症是一种病因复杂的精神健康障碍。环境应激、神经发育以及其他因素共同导致抑郁症的发生。尤其是对于伴有慢性负性应激的抑郁症，由于其机制不明，具有复发率高和疗效差的特点。在此，我们根据静息态功能磁共振成像研究了经历慢性负性应激的抑郁症患者的海马结构和功能连接（FC）。
本研究共纳入65例抑郁症患者（34例经历慢性负性应激，31例未经历慢性负性应激）和30例未经历慢性负性应激的健康对照。比较三组之间海马亚区的体积、基于种子点的海马与全脑体素之间的功能连接以及基于感兴趣区（ROI）的海马亚区之间的功能连接。
在经历慢性负性应激的抑郁症患者中，右侧齿状回颗粒细胞下层-分子层-头部（right_GC-ML-DG-head）、右侧海马CA4头部（right_CA4-head）和右侧海马CA3头部（right_CA3-head）的体积增大，颞中回右侧（Temporal_Mid_R）、楔前叶右侧（Precuneus_R）、额上回右侧（Frontal_Sup_R）、颞上回右侧（Temporal_Sup_R）、角回左侧（Angular_L）、额下回三角部右侧（Frontal_Inf_Tri_R）、辅助运动区右侧（Supp_Motor_Area_R）、中央前回左侧（Precentral_L）与海马之间的功能连接增强，副下托与CA3之间以及前下托与CA1之间的功能连接减弱。与未经历慢性负性应激的抑郁症患者相比，经历慢性负性应激的患者右侧齿状回颗粒细胞下层-分子层-头部和右侧海马CA3头部的体积更大，额上回右侧、额下回三角部右侧与海马之间的功能连接更强，前下托与CA1之间的功能连接更弱。
经历慢性负性应激的抑郁症患者可能存在海马结构和功能连接的破坏。这可能是潜在的抑郁症亚型之一。
