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乳脂中三酰甘油异构体检测的进展

Progress in triacylglycerol isomer detection in milk lipids.

作者信息

Cao Huiru, Liu Qian, Liu Yan, Zhao Junying, Qiao Weicang, Wang Yuru, Liu Yan, Chen Lijun

机构信息

Key Laboratory of Dairy Science, Ministry of Education, Food Science College, Northeast Agricultural University, Harbin 150030, China.

National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing 100163, China.

出版信息

Food Chem X. 2024 May 3;22:101433. doi: 10.1016/j.fochx.2024.101433. eCollection 2024 Jun 30.

DOI:10.1016/j.fochx.2024.101433
PMID:38764784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11101684/
Abstract

In triacylglycerols (TAGs), position differences of fatty acids on the glycerol skeleton produce various TAG isomers. These TAG isomers have different pathways of digestion, absorption, and utilization in infants, thereby affecting TAG nutritional properties of TAGs. Here, we review the progress of research on methods for detecting TAG isomers, and identify direction and thought for improving these methods, including novel chromatographic combinations, perfect algorithm, and improved equipment. The ensuing optimization of these methods is expected to provide robust guarantee for the gradual improvement of milk-derived TAG isomer detection, and is an important prerequisite for infant formula to mimic the structured lipids of human milk.

摘要

在三酰甘油(TAGs)中,脂肪酸在甘油骨架上的位置差异会产生各种TAG异构体。这些TAG异构体在婴儿体内具有不同的消化、吸收和利用途径,从而影响TAGs的TAG营养特性。在此,我们综述了TAG异构体检测方法的研究进展,并确定了改进这些方法的方向和思路,包括新型色谱组合、完善的算法和改进的设备。对这些方法的后续优化有望为逐步改进乳源性TAG异构体检测提供有力保障,并且是婴儿配方奶粉模拟人乳结构化脂质的重要前提。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c584/11101684/b6687d6a4a4a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c584/11101684/28f99e43f939/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c584/11101684/4ce4df34d0f6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c584/11101684/b6687d6a4a4a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c584/11101684/28f99e43f939/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c584/11101684/4ce4df34d0f6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c584/11101684/b6687d6a4a4a/gr3.jpg

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本文引用的文献

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Detection and analysis of triacylglycerol regioisomers via electron activated dissociation (EAD) tandem mass spectrometry.通过电子激活解离(EAD)串联质谱法检测和分析三酰基甘油区域异构体。
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一种人乳脂肪替代品的三酰甘油结构和组成会影响刚断奶的 Sprague-Dawley 大鼠对脂肪酸和钙的吸收、脂质代谢和胆汁酸代谢。
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Impact of column temperature on triacylglycerol regioisomers separation in silver ion liquid chromatography using heptane-based mobile phases.正庚烷体系中柱温对银离子液相色谱分离三酰甘油立体异构体的影响。
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Direct Chiral Supercritical Fluid Chromatography-Mass Spectrometry Analysis of Monoacylglycerol and Diacylglycerol Isomers for the Study of Lipase-Catalyzed Hydrolysis of Triacylglycerols.用于研究脂肪酶催化三酰甘油水解的单酰甘油和二酰甘油异构体的直接手性超临界流体色谱-质谱分析
Anal Chem. 2023 Mar 21;95(11):5109-5116. doi: 10.1021/acs.analchem.3c00053. Epub 2023 Mar 9.
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A GC/MS method for the rapid determination of disaturated triacylglycerol positional isomers.一种用于快速测定二饱和三酰甘油位置异构体的气相色谱/质谱联用方法。
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