Gildea Edwina, Scales-Theobald Emma, Thompson Jill, Cook Alasdair, Forde Katie, Skingley George, Lawrie Sophie, Williamson Nicola, Panter Charlotte
Zoetis International, Dublin, Ireland.
School of Veterinary Medicine, University of Surrey, Surrey, United Kingdom.
Front Vet Sci. 2024 May 3;11:1377019. doi: 10.3389/fvets.2024.1377019. eCollection 2024.
Canine osteoarthritis (OA) causes pain and mobility impairment. This can reduce dog quality of life (QoL), owner QoL and owners' satisfaction with, and adherence to, treatments. No existing canine OA-specific instrument assesses all three impacts. This study aimed to develop and psychometrically evaluate an owner-completed canine OA-specific measure of dog QoL, owner QoL and owner treatment satisfaction; the "Canine OA Quality of Life and Treatment Satisfaction Questionnaire" (CaOA-QoL-TS).
The CaOA-QoL-TS was developed using a conceptual model derived from a meta-synthesis of published literature followed by cognitive interviews with ten owners of dogs with OA, to evaluate content validity.
Based on interview findings, ten items were reworded, four removed, and two added; resulting in 26 items that all owners understood and considered relevant. The recall period and response options were well understood and appropriate to almost all owners. To evaluate its psychometric properties, the CaOA-QoL-TS (draft 26-item version) was administered, across six timepoints in a phase 4 field study, to owners of OA treated dogs, recruited from veterinary practices ( = 93). Inter-item correlations suggested items clustered into three distinct domains: Dog QoL, Owner QoL and Treatment Satisfaction, as hypothesized. Confirmatory factor analysis supported deletion of two items and calculation of the three domain scores, with acceptable model fit. The resulting 24-item CaOA-QoL-TS instrument demonstrated strong internal consistency and good to excellent test-retest reliability. Convergent validity was supported by moderate to strong correlations with concurrent measures. Known groups validity was supported by statistically significant differences between groups categorized by owner global impression of QoL. Ability to detect change was demonstrated through statistically significant improvements over time in Owner and Dog QoL, with larger within-group effect sizes reported for the mean of 'improved' dogs compared to the mean of 'stable' dogs. Only a small sample of dogs worsened throughout the study. Anchor-based analyses supported-0.9 and-1.0-point within-group responder definitions for dog and owner QoL domains, respectively.
Findings support the content validity of the CaOA-QoL-TS in canine OA. The 24-item CaOA-QoL-TS is a reliable and valid instrument to measure owner and canine QoL and TS and is sensitive to improvements following OA treatment.
犬骨关节炎（OA）会导致疼痛和行动障碍。这会降低犬的生活质量（QoL）、主人的生活质量以及主人对治疗的满意度和依从性。现有的针对犬OA的工具均无法评估这三方面的影响。本研究旨在开发并从心理测量学角度评估一种由主人填写的、针对犬OA的、用于测量犬生活质量、主人生活质量及主人治疗满意度的工具；即“犬骨关节炎生活质量与治疗满意度问卷”（CaOA-QoL-TS）。
CaOA-QoL-TS是根据已发表文献的元综合得出的概念模型开发的，随后对十名患有OA的犬的主人进行了认知访谈，以评估内容效度。
根据访谈结果，对十个项目进行了重新措辞，删除了四个项目，并增加了两个项目；最终形成了26个所有主人都理解且认为相关的项目。回忆期和回答选项几乎为所有主人所理解且合适。为评估其心理测量特性，在一项4期现场研究的六个时间点，向从兽医诊所招募的接受OA治疗的犬的主人发放了CaOA-QoL-TS（26项版本草案）（n = 93）。项目间相关性表明，项目聚类为三个不同的领域：犬生活质量、主人生活质量和治疗满意度，与假设一致。验证性因素分析支持删除两个项目并计算三个领域得分，模型拟合度可接受。最终得到的24项CaOA-QoL-TS工具显示出很强的内部一致性和良好到优秀的重测信度。与并行测量的中度到强相关性支持了收敛效度。通过主人对生活质量的总体印象进行分类的组间统计学显著差异支持了已知组效度。通过主人和犬生活质量随时间的统计学显著改善证明了检测变化的能力，与“稳定”犬的均值相比，“改善”犬的均值报告的组内效应量更大。在整个研究过程中，只有一小部分犬的情况恶化。基于锚定的分析分别支持犬和主人生活质量领域内组内应答者定义为-0.9分和-1.0分。
研究结果支持CaOA-QoL-TS在犬OA中的内容效度。24项CaOA-QoL-TS是一种可靠且有效的工具，可用于测量主人和犬的生活质量及治疗满意度，并且对OA治疗后的改善敏感。
